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Mouse Monoclonal PDK1 antibody [4A11] (STJ98315)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, FC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for PDK1 Monoclonal Antibody.
Check alternative names for the antibodyExpand
PDK1 antibody, PDHK1 antibody,|[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial antibody|HGNC:8809 antibody|Mitochondrial pyruvate dehydrogenase kinase isoenzyme 1 antibody|PDH kinase 1 antibody|Pdk1 antibody|PDK1_HUMAN antibody|Pyruvate dehydrogenase kinase isoform 1 antibody|Pyruvate dehydrogenase kinase, isoenzyme 1 antibody|Anti-Mitochondrial Pyruvate dehydrogenase kinase 1 antibody [4A11] (ab110025)
SCBT cat No: sc-28783|sc-293160|sc-7140|sc-30691|
PDK1 Monoclonal Antibody
|Catalogue No.|| |
Human, Rat, Monkey
PDK1 Monoclonal Antibody detects endogenous levels of PDK1 protein.
Purified recombinant fragment of human PDK1 expressed in E Coli
WB, IHC, IF, FC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
PDK1 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
PDK1 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
kinase isozyme 1, mitochondrial antibody, Pyruvate dehydrogenase kinase isoform 1 antibody, PDH kinase 1 antibody
|Protein names|| |
kinase isozyme 1, mitochondrial , Pyruvate dehydrogenase kinase isoform 1 , PDH kinase 1
|Protein function|| |
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress. / ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate. / Activity is enhanced by binding to the pyruvate dehydrogenase subunit DLAT. Inhibited by AZD7545; this compound interferes with DLAT binding and thereby inhibits kinase activity. Inhibited by dichloroacetate and radicicol.
|Protein tissue specificity|| |
Expressed predominantly in the heart. Detected at lower levels in liver, skeletal muscle and pancreas.
|Protein sequence and domain|| |
Belongs to the PDK/BCKDK protein kinase family. / Contains 1 histidine kinase domain.
|Protein post-translational modifications|| |
Phosphorylated by constitutively activated ABL1, FGFR1, FLT3 and JAK2 (in vitro), and this may also occur in cancer cells that express constitutively activated ABL1, FGFR1, FLT3 and JAK2. Phosphorylation at Tyr-243 and Tyr-244 strongly increases kinase activity, while phosphorylation at Tyr-136 has a lesser effect.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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