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Mouse Monoclonal PGC-1alpha antibody [1G8] (STJ98321)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
PPARGC1A antibody, LEM6 antibody, PGC1 antibody, PGC1A antibody, PPARGC1 antibody,|L PGC 1alpha antibody|LEM6 antibody|Ligand effect modulator 6 antibody|Peroxisome proliferative activated receptor gamma coactivator 1 alpha antibody|Peroxisome proliferative activated receptor gamma coactivator 1 antibody|Peroxisome proliferator activated receptor gamma coactivator 1 alpha antibody|Peroxisome proliferator activated receptor gamma coactivator 1 alpha transcript variant B4 3ext antibody|Peroxisome proliferator activated receptor gamma coactivator 1 alpha transcript variant B4 8a antibody|Peroxisome proliferator activated receptor gamma coactivator 1 alpha transcript variant B4 antibody|Peroxisome proliferator activated receptor gamma coactivator 1 alpha transcript variant B5 antibody|Peroxisome proliferator activated receptor gamma coactivator 1 alpha transcript variant B5 NT antibody|Peroxisome proliferator-activated receptor gamma coactivator 1-alpha antibody|PGC 1 (alpha) antibody|PGC 1 alpha antibody|PGC 1v antibody|PGC-1-alpha antibody|PGC1 antibody|PGC1(alpha) antibody|PGC1A antibody|PGC1v antibody|PPAR gamma coactivator 1 alpha 3 ligand effect modulator 6 antibody|PPAR gamma coactivator 1 alpha antibody|PPAR gamma coactivator 1 antibody|PPAR gamma coactivator variant form antibody|PPAR-gamma coactivator 1-alpha antibody|PPARGC 1 alpha antibody|PPARGC-1-alpha antibody|PPARGC1 antibody|PPARGC1A antibody|PRGC1_HUMAN antibody|Anti-PGC1 alpha antibody (ab54481)
SCBT cat No: sc-293168|sc-13067|sc-5816|sc-5815|
PGC-1alpha Monoclonal Antibody
|Catalogue No.|| |
PGC-1alpha Monoclonal Antibody detects endogenous levels of PGC-1alpha protein.
Purified recombinant fragment of human PGC-1alpha expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
PGC-1alpha Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
PGC-1alpha Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha antibody, PGC-1-alpha antibody, PPAR-gamma coactivator 1-alpha antibody, PPARGC-1-alpha antibody, Ligand effect modulator 6 antibody
|Protein names|| |
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha , PGC-1-alpha , PPAR-gamma coactivator 1-alpha , PPARGC-1-alpha , Ligand effect modulator 6
|Protein function|| |
Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.
|Protein tissue specificity|| |
Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects.
|Protein sequence and domain|| |
Contains 1 RRM (RNA recognition motif) domain.
|Protein post-translational modifications|| |
Phosphorylation by AMPK in skeletal muscle increases activation of its own promoter. Phosphorylated by CLK2. / Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions. / Ubiquitinated. Ubiquitination by RNF34 induces proteasomal degradation.
|Protein cellular localization|| |
Nucleus / Nucleus > PML body / Nucleus / Cytoplasm / Nucleus / Nucleus / Nucleus > PML body / Nucleus
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St John’s Laboratory Ltd.
|Product type|| |
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