Mouse Monoclonal Podocalyxin-like 1 antibody [5D4] (STJ98327)

$379.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Podocalyxin-like 1 antibody [5D4] (STJ98327)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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PODXL antibody, PCLP antibody, PCLP1 antibody,|GCTM-2 antigen antibody|Gp2 antibody|Gp200 antibody|MGC138240 antibody|PC antibody|PCLP antibody|PCLP-1 antibody|PCLP1 antibody|Pcx antibody|Podocalyxin antibody|Podocalyxin like antibody|Podocalyxin like protein antibody|Podocalyxin-like protein 1 antibody|Podxl antibody|PODXL_HUMAN antibody|Anti-PODXL antibody [EPR9518] (ab150358)
SCBT cat No: sc-23904|sc-23903|sc-393716|sc-33138|sc-10503|sc-33139|sc-10506|

 

Name

Podocalyxin-like 1 Monoclonal Antibody

Catalogue No.

STJ98327

Reactivity

Human

Specificity

Podocalyxin-like 1 Monoclonal Antibody detects endogenous levels of Podocalyxin-like 1 protein.

Immunogen

Purified recombinant fragment of human Podocalyxin-like 1 expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

Podocalyxin-like 1 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

Podocalyxin-like 1 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Podocalyxin antibody, GCTM-2 antigen antibody, Gp200 antibody, Podocalyxin-like protein 1 antibody, PC antibody, PCLP-1 antibody

Database links

Human UniProt/Swiss-Prot:O00592;Mouse UniPort/Swiss-Prot: Q9R0M4;Rat UniProt/Swiss-Port: Q9WTQ2;Human Entrez Gene: 5420;Mouse Entrez Gene: 27205;Rat Entrez Gene: Rn.162741

Protein names

Podocalyxin , GCTM-2 antigen , Gp200 , Podocalyxin-like protein 1 , PC , PCLP-1

Protein function

Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.

Protein tissue specificity

Glomerular epithelium cell (podocyte).

Protein sequence and domain

Both the O-glycan-rich domain of the extracellular domain and the C-terminus PDZ-binding motif (DTHL) in the cytoplasmic tail harbor an apical sorting signal. The cytoplasmic domain is necessary for the apical membrane targeting and renal tubulogenesis. The cytoplasmic C-terminus PDZ-binding motif (DTHL) is essential for interaction with SLC9A3R1 and for targeting SLC9A3R1 to the apical cell membrane. The extracellular domain is necessary for microvillus formation (By similarity). The large highly anionic extracellular domain allows to maintain open filtration pathways between neighboring podocyte foot processes. / Belongs to the podocalyxin family.

Protein post-translational modifications

N- and O-linked glycosylated. Sialoglycoprotein (By similarity).

Protein cellular localization

Apical cell membrane / Cell projection > lamellipodium / Cell projection > filopodium / Cell projection > ruffle / Cell projection > microvillus / Membrane raft / Membrane

Research area

All research areas>Cell Adhesion Proteins>Podocalyxin-like
(View all antibody categories related to Cell Adhesion Proteins)

Note

AntibodyPlus can customize Podocalyxin-like 1 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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