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Mouse Monoclonal Podocalyxin-like 1 antibody [5F5] (STJ98328)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, FC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
PODXL antibody, PCLP antibody, PCLP1 antibody,|GCTM-2 antigen antibody|Gp2 antibody|Gp200 antibody|MGC138240 antibody|PC antibody|PCLP antibody|PCLP-1 antibody|PCLP1 antibody|Pcx antibody|Podocalyxin antibody|Podocalyxin like antibody|Podocalyxin like protein antibody|Podocalyxin-like protein 1 antibody|Podxl antibody|PODXL_HUMAN antibody|Anti-PODXL antibody [EPR9518] (ab150358)
SCBT cat No: sc-23904|sc-23903|sc-393716|sc-33138|sc-10503|sc-33139|sc-10506|
Podocalyxin-like 1 Monoclonal Antibody
|Catalogue No.|| |
Podocalyxin-like 1 Monoclonal Antibody detects endogenous levels of Podocalyxin-like 1 protein.
Purified recombinant fragment of human Podocalyxin-like 1 expressed in E Coli
WB, IHC, FC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
Podocalyxin-like 1 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
Podocalyxin-like 1 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Podocalyxin antibody, GCTM-2 antigen antibody, Gp200 antibody, Podocalyxin-like protein 1 antibody, PC antibody, PCLP-1 antibody
|Protein names|| |
Podocalyxin , GCTM-2 antigen , Gp200 , Podocalyxin-like protein 1 , PC , PCLP-1
|Protein function|| |
Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
|Protein tissue specificity|| |
Glomerular epithelium cell (podocyte).
|Protein sequence and domain|| |
Both the O-glycan-rich domain of the extracellular domain and the C-terminus PDZ-binding motif (DTHL) in the cytoplasmic tail harbor an apical sorting signal. The cytoplasmic domain is necessary for the apical membrane targeting and renal tubulogenesis. The cytoplasmic C-terminus PDZ-binding motif (DTHL) is essential for interaction with SLC9A3R1 and for targeting SLC9A3R1 to the apical cell membrane. The extracellular domain is necessary for microvillus formation (By similarity). The large highly anionic extracellular domain allows to maintain open filtration pathways between neighboring podocyte foot processes. / Belongs to the podocalyxin family.
|Protein post-translational modifications|| |
N- and O-linked glycosylated. Sialoglycoprotein (By similarity).
|Protein cellular localization|| |
Apical cell membrane / Cell projection > lamellipodium / Cell projection > filopodium / Cell projection > ruffle / Cell projection > microvillus / Membrane raft / Membrane
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St John’s Laboratory Ltd.
|Product type|| |
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