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Mouse Monoclonal PP1alpha antibody (STJ98532)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC
Recommended dilution: WB 1:1000-1:2000; IHC 1:500-1:1000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
PPP1CA antibody, PPP1A antibody,|PP-1A antibody|PP-1B antibody|PP1A antibody|PP1alpha antibody|PP1B antibody|PP1beta antibody|PPP1A antibody|PPP1CD antibody|protein phosphatase 1 catalytic subunit alpha isozyme antibody|protein phosphatase 1 catalytic subunit beta isoform antibody|protein phosphatase 1 catalytic subunit delta isoform antibody|serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit antibody|Serine/threonine-protein phosphatase PP1-alpha catalytic subunit antibody|Serine/threonine-protein phosphatase PP1-beta catalytic subunit antibody|Anti-PPP1CA + 1CB antibody [EP1511Y] (ab52619)
SCBT cat No: sc-517233|sc-365678|sc-6106|sc-373782|sc-377125|sc-373783|sc-6107|
PP1alpha Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat, Pig, Rabbit
PP1alpha Monoclonal Antibody detects endogenous levels of PP1alpha protein.
Purified recombinant human PP1alpha protein fragments expressed in Ecoli
|Recommended dilution|| |
WB 1:1000-1:2000; IHC 1:500-1:1000
PP1alpha Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
PP1alpha Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit antibody, PP-1A antibody,
|Protein names|| |
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit , PP-1A ,
|Protein function|| |
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the ‘Ser-418’ residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective . / [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate. / Fe cation / Mn2+ / The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.
|Protein tissue specificity|| |
Up-regulated in synovial fluid mononuclear cells and peripheral blood mononuclear cells from patients with rheumatoid arthritis.
|Protein sequence and domain|| |
Belongs to the PPP phosphatase family. PP-1 subfamily.
|Protein post-translational modifications|| |
Phosphorylated. Dephosphorylated at Thr-320 in the presence of ionizing radiation.
|Protein cellular localization|| |
Cytoplasm / Nucleus / Nucleus > nucleoplasm / Nucleus > nucleolus
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St John’s Laboratory Ltd.
|Product type|| |
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