Mouse Monoclonal PP2A-Calpha antibody (STJ98535)

$379.00

Reactivity: Human, Mouse, Cow, Chicken, Dog, Pig, Rabbit, Zebrafish
Applications: WB, IF
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

Mouse Monoclonal PP2A-Calpha antibody (STJ98535)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IF

Recommended dilution: WB 1:1000-1:2000; IF 1:100-1:500

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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PPP2CA antibody,|PP2A alpha antibody|PP2A-alpha antibody|PP2AA_HUMAN antibody|PP2Aalpha antibody|PP2Ac antibody|PP2CA antibody|PP2Calpha antibody|PPP2CA antibody|Protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform antibody|Protein phosphatase 2 catalytic subunit alpha isoform antibody|Protein phosphatase 2, catalytic subunit, alpha isozyme antibody|Protein phosphatase 2A catalytic subunit, alpha isoform antibody|Replication protein C antibody|RP C antibody|RP-C antibody|RPC antibody|Serine/threonine protein phosphatase 2A catalytic subunit alpha isoform antibody|Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform antibody|Anti-PP2A-alpha antibody (ab137825)
SCBT cat No: sc-13601|sc-80990|sc-167616|sc-138914|sc-246424|sc-398374|sc-390685|sc-87080|sc-160276|sc-514660|sc-246432|

 

Name

PP2A-Calpha Monoclonal Antibody

Catalogue No.

STJ98535

Reactivity

Human, Mouse, Cow, Chicken, Dog, Pig, Rabbit, Zebrafish

Specificity

PP2A-Calpha Monoclonal Antibody detects endogenous levels of PP2A-Calpha protein.

Immunogen

Purified recombinant human PP2A-Calpha (N-terminus) protein fragments expressed in Ecoli

Host

Mouse

Applications

WB, IF

Recommended dilution

WB 1:1000-1:2000; IF 1:100-1:500

Clonality

Monoclonal

Conjugation

Unconjugated

Formulation

PP2A-Calpha Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Concentration

1 mg/ml

Purification

PP2A-Calpha Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform antibody, PP2A-alpha antibody, Replication protein C antibody, RP-C antibody

Database links

Human UniProt/Swiss-Prot:P67775;Mouse UniPort/Swiss-Prot: P63330;Rat UniProt/Swiss-Port: P63331;Human Entrez Gene: 5515;Mouse Entrez Gene: 19052;Rat Entrez Gene: Rn.1271

Protein names

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform , PP2A-alpha , Replication protein C , RP-C

Protein function

PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at ‘Ser-259’. / [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate. / Mn2+

Protein sequence and domain

Belongs to the PPP phosphatase family. PP-1 subfamily.

Protein post-translational modifications

Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme’s substrate specificity, enzyme activity and cellular localization. / Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation. / May be monoubiquitinated by NOSIP.

Protein cellular localization

Cytoplasm / Nucleus / Chromosome > centromere / Cytoplasm > cytoskeleton > spindle pole

Research area

All research areas>Kinases and Phosphatases>PP2A-C alpha / beta
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize PP2A-Calpha Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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