Mouse Monoclonal PP2A-Calpha antibody (STJ98535)


Reactivity: Human, Mouse, Cow, Chicken, Dog, Pig, Rabbit, Zebrafish
Applications: WB, IF
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

Mouse Monoclonal PP2A-Calpha antibody (STJ98535)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IF

Recommended dilution: WB 1:1000-1:2000; IF 1:100-1:500

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody


PPP2CA antibody,|PP2A alpha antibody|PP2A-alpha antibody|PP2AA_HUMAN antibody|PP2Aalpha antibody|PP2Ac antibody|PP2CA antibody|PP2Calpha antibody|PPP2CA antibody|Protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform antibody|Protein phosphatase 2 catalytic subunit alpha isoform antibody|Protein phosphatase 2, catalytic subunit, alpha isozyme antibody|Protein phosphatase 2A catalytic subunit, alpha isoform antibody|Replication protein C antibody|RP C antibody|RP-C antibody|RPC antibody|Serine/threonine protein phosphatase 2A catalytic subunit alpha isoform antibody|Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform antibody|Anti-PP2A-alpha antibody (ab137825)
SCBT cat No: sc-13601|sc-80990|sc-167616|sc-138914|sc-246424|sc-398374|sc-390685|sc-87080|sc-160276|sc-514660|sc-246432|



PP2A-Calpha Monoclonal Antibody

Catalogue No.



Human, Mouse, Cow, Chicken, Dog, Pig, Rabbit, Zebrafish


PP2A-Calpha Monoclonal Antibody detects endogenous levels of PP2A-Calpha protein.


Purified recombinant human PP2A-Calpha (N-terminus) protein fragments expressed in Ecoli





Recommended dilution

WB 1:1000-1:2000; IF 1:100-1:500






PP2A-Calpha Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.


1 mg/ml


PP2A-Calpha Antibody was purified using affinity purification.


-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform antibody, PP2A-alpha antibody, Replication protein C antibody, RP-C antibody

Database links

Human UniProt/Swiss-Prot:P67775;Mouse UniPort/Swiss-Prot: P63330;Rat UniProt/Swiss-Port: P63331;Human Entrez Gene: 5515;Mouse Entrez Gene: 19052;Rat Entrez Gene: Rn.1271

Protein names

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform , PP2A-alpha , Replication protein C , RP-C

Protein function

PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at ‘Ser-259’. / [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate. / Mn2+

Protein sequence and domain

Belongs to the PPP phosphatase family. PP-1 subfamily.

Protein post-translational modifications

Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme’s substrate specificity, enzyme activity and cellular localization. / Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation. / May be monoubiquitinated by NOSIP.

Protein cellular localization

Cytoplasm / Nucleus / Chromosome > centromere / Cytoplasm > cytoskeleton > spindle pole

Research area

All research areas>Kinases and Phosphatases>PP2A-C alpha / beta
(View all antibody categories related to Kinases and Phosphatases)


AntibodyPlus can customize PP2A-Calpha Antibody according to your requirement, including bulk product size,etc. Please contact AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.


St John’s Laboratory Ltd.

Product type

Primary antibody


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