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Mouse Monoclonal PP5 antibody (STJ98537)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB
Recommended dilution: WB 1:1000-1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for PP5 Monoclonal Antibody.
Check alternative names for the antibodyExpand
PPP5C antibody, PPP5 antibody,|FLJ36922 antibody|FLJ55954 antibody|OTTHUMP00000165834 antibody|PP-T antibody|PP5 antibody|PPP5 antibody|PPP5_HUMAN antibody|Ppp5c antibody|PPT antibody|Protein phosphatase 5, catalytic subunit antibody|Protein phosphatase T antibody|Serine/threonine protein phosphatase 5 antibody|Serine/threonine-protein phosphatase 5 antibody|Anti-PP5 antibody (ab26053)
SCBT cat No: sc-136046|sc-32588|sc-32587|sc-271612|sc-271817|sc-271613|sc-515257|sc-271816|
PP5 Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
PP5 Monoclonal Antibody detects endogenous levels of PP5 protein.
Purified recombinant human PP5 protein fragments expressed in Ecoli
|Recommended dilution|| |
PP5 Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
PP5 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Serine/threonine-protein phosphatase 5 antibody, PP5 antibody, Protein phosphatase T antibody, PP-T antibody, PPT antibody
|Protein names|| |
Serine/threonine-protein phosphatase 5 , PP5 , Protein phosphatase T , PP-T , PPT
|Protein function|| |
Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2. / [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate. / Mg2+, Mn2+ / Autoinhibited. In the autoinhibited state, the TPR domain interacts with the catalytic region and prevents substrate access to the catalytic pocket. Allosterically activated by various polyunsaturated fatty acids, free long-chain fatty-acids and long-chain fatty acyl-CoA esters, arachidonic acid being the most effective activator. HSP90A and probably RAC1, GNA12 and GNA13 can also release the autoinhibition by the TPR repeat. Activation by RAC1, GNA12 and GNA13 is synergistic with the one produced by fatty acids binding. Inhibited by okadaic acid. / 1.847 µM for CSNK1E (at 30 degrees Celsius) / 13.2 µM for MAPT/TAU (at pH 7.4 and 30 degrees Celsius)
|Protein tissue specificity|| |
|Protein sequence and domain|| |
Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily. / Contains 3 TPR repeats.
|Protein post-translational modifications|| |
Activated by at least two different proteolytic cleavages producing a 56 kDa and a 50 kDa form.
|Protein cellular localization|| |
Nucleus / Cytoplasm / Cell membrane
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St John’s Laboratory Ltd.
|Product type|| |
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