Mouse Monoclonal PP5 antibody (STJ98537)

$379.00

Reactivity: Human, Mouse, Rat
Applications: WB
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal PP5 antibody (STJ98537)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB

Recommended dilution: WB 1:1000-1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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PPP5C antibody, PPP5 antibody,|FLJ36922 antibody|FLJ55954 antibody|OTTHUMP00000165834 antibody|PP-T antibody|PP5 antibody|PPP5 antibody|PPP5_HUMAN antibody|Ppp5c antibody|PPT antibody|Protein phosphatase 5, catalytic subunit antibody|Protein phosphatase T antibody|Serine/threonine protein phosphatase 5 antibody|Serine/threonine-protein phosphatase 5 antibody|Anti-PP5 antibody (ab26053)
SCBT cat No: sc-136046|sc-32588|sc-32587|sc-271612|sc-271817|sc-271613|sc-515257|sc-271816|

 

Name

PP5 Monoclonal Antibody

Catalogue No.

STJ98537

Reactivity

Human, Mouse, Rat

Specificity

PP5 Monoclonal Antibody detects endogenous levels of PP5 protein.

Immunogen

Purified recombinant human PP5 protein fragments expressed in Ecoli

Host

Mouse

Applications

WB

Recommended dilution

WB 1:1000-1:2000

Clonality

Monoclonal

Conjugation

Unconjugated

Formulation

PP5 Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Concentration

1 mg/ml

Purification

PP5 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Serine/threonine-protein phosphatase 5 antibody, PP5 antibody, Protein phosphatase T antibody, PP-T antibody, PPT antibody

Database links

Human UniProt/Swiss-Prot:P53041;Mouse UniPort/Swiss-Prot: Q60676;Rat UniProt/Swiss-Port: P53042;Human Entrez Gene: 5536;Mouse Entrez Gene: 19060;Rat Entrez Gene: Rn.6107

Protein names

Serine/threonine-protein phosphatase 5 , PP5 , Protein phosphatase T , PP-T , PPT

Protein function

Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2. / [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate. / Mg2+, Mn2+ / Autoinhibited. In the autoinhibited state, the TPR domain interacts with the catalytic region and prevents substrate access to the catalytic pocket. Allosterically activated by various polyunsaturated fatty acids, free long-chain fatty-acids and long-chain fatty acyl-CoA esters, arachidonic acid being the most effective activator. HSP90A and probably RAC1, GNA12 and GNA13 can also release the autoinhibition by the TPR repeat. Activation by RAC1, GNA12 and GNA13 is synergistic with the one produced by fatty acids binding. Inhibited by okadaic acid. / 1.847 µM for CSNK1E (at 30 degrees Celsius) / 13.2 µM for MAPT/TAU (at pH 7.4 and 30 degrees Celsius)

Protein tissue specificity

Ubiquitous.

Protein sequence and domain

Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily. / Contains 3 TPR repeats.

Protein post-translational modifications

Activated by at least two different proteolytic cleavages producing a 56 kDa and a 50 kDa form.

Protein cellular localization

Nucleus / Cytoplasm / Cell membrane

Research area

All research areas>Kinases and Phosphatases>PP5
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize PP5 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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