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Mouse Monoclonal PPAR-gamma antibody [3A4A9; 1E6A1] (STJ98330)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
PPARG antibody, NR1C3 antibody,|CIMT1 antibody|GLM1 antibody|NR1C3 antibody|Nuclear receptor subfamily 1 group C member 3 antibody|OTTHUMP00000185032 antibody|OTTHUMP00000185036 antibody|Peroxisome proliferator activated nuclear receptor gamma variant 1 antibody|Peroxisome proliferator activated receptor gamma 1 antibody|Peroxisome Proliferator Activated Receptor gamma antibody|Peroxisome proliferator-activated receptor gamma antibody|PPAR gamma antibody|PPAR-gamma antibody|PPARG antibody|PPARG_HUMAN antibody|PPARG1 antibody|PPARG2 antibody|PPARgamma antibody|Anti-PPAR gamma antibody – ChIP Grade (ab45036)
SCBT cat No: sc-81152|sc-271392|sc-1981|sc-7273|sc-7196|sc-6285|sc-6284|sc-1984|sc-166731|sc-390740|sc-22020|sc-22022|sc-135704|
PPAR-gamma Monoclonal Antibody
|Catalogue No.|| |
PPAR-gamma Monoclonal Antibody detects endogenous levels of PPAR-gamma protein.
Purified recombinant fragment of PPAR-gamma (aa170-270) expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
PPAR-gamma Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
PPAR-gamma Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Peroxisome proliferator-activated receptor gamma antibody, PPAR-gamma antibody, Nuclear receptor subfamily 1 group C member 3 antibody
|Protein names|| |
Peroxisome proliferator-activated receptor gamma , PPAR-gamma , Nuclear receptor subfamily 1 group C member 3
|Protein function|| |
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity). / PDPK1 activates its transcriptional activity independently of its kinase activity.
|Protein tissue specificity|| |
Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary.
|Involvement in disease|| |
Note: Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer. .; Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. . Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry.; Lipodystrophy, familial partial, 3 (FPLD3) [MIM:604367]: A form of lipodystrophy characterized by marked loss of subcutaneous fat from the extremities. Facial adipose tissue may be increased, decreased or normal. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Glioma 1 (GLM1) [MIM:137800]: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes. . Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry. Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility.
|Protein sequence and domain|| |
Belongs to the nuclear hormone receptor family. NR1 subfamily. / Contains 1 nuclear receptor DNA-binding domain.
|Protein post-translational modifications|| |
O-GlcNAcylation at Thr-84 reduces transcriptional activity in adipocytes. / Phosphorylated in basal conditions and dephosphorylated when treated with the ligand. May be dephosphorylated by PPP5C. The phosphorylated form may be inactive and dephosphorylation at Ser-112 induces adipogenic activity (By similarity).
|Protein cellular localization|| |
Nucleus / Cytoplasm
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St John’s Laboratory Ltd.
|Product type|| |
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