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Mouse Monoclonal PPX antibody (STJ98539)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF
Recommended dilution: WB 1:1000-1:2000; IHC 1:500-1:1000; IF 1:100-1:500
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
PPP4C antibody, PPP4 antibody, PPX antibody,|PP X antibody|PP-X antibody|Pp4 antibody|PP4C antibody|PP4C_HUMAN antibody|PPH3 antibody|PPP4 antibody|ppp4c antibody|PPX antibody|protein phosphatase 4 (formerly X), catalytic subunit antibody|Protein phosphatase 4 catalytic subunit antibody|Protein phosphatase X antibody|protein phosphatase X, catalytic subunit antibody|Serine/threonine protein phosphatase 4 catalytic subunit antibody|Serine/threonine-protein phosphatase 4 catalytic subunit antibody|Anti-PPP4C antibody [EPR19502] (ab195371)
SCBT cat No: sc-6118|sc-374106|
PPX Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat, Cow, Dog, Zebrafish
PPX Monoclonal Antibody detects endogenous levels of PPX protein.
Purified recombinant human PPX protein fragments expressed in Ecoli
WB, IHC, IF
|Recommended dilution|| |
WB 1:1000-1:2000; IHC 1:500-1:1000; IF 1:100-1:500
PPX Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
PPX Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Serine/threonine-protein phosphatase 4 catalytic subunit antibody, PP4C antibody, Pp4 antibody, Protein phosphatase X antibody, PP-X antibody
|Protein names|| |
Serine/threonine-protein phosphatase 4 catalytic subunit , PP4C , Pp4 , Protein phosphatase X , PP-X
|Protein function|| |
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin. / [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate. / Mn2+
|Protein sequence and domain|| |
Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.
|Protein post-translational modifications|| |
Methylation at the C-terminal Leu-307 is critical for interactions with regulatory subunits and functions in DNA repair.
|Protein cellular localization|| |
Cytoplasm / Nucleus / Cytoplasm > cytoskeleton > microtubule organizing center > centrosome
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St John’s Laboratory Ltd.
|Product type|| |
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