Mouse Monoclonal PPX antibody (STJ98539)

$379.00

Reactivity: Human, Mouse, Rat, Cow, Dog, Zebrafish
Applications: WB, IHC, IF
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal PPX antibody (STJ98539)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF

Recommended dilution: WB 1:1000-1:2000; IHC 1:500-1:1000; IF 1:100-1:500

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for PPX Monoclonal Antibody.

Alternative names:

Check alternative names for the antibody

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PPP4C antibody, PPP4 antibody, PPX antibody,|PP X antibody|PP-X antibody|Pp4 antibody|PP4C antibody|PP4C_HUMAN antibody|PPH3 antibody|PPP4 antibody|ppp4c antibody|PPX antibody|protein phosphatase 4 (formerly X), catalytic subunit antibody|Protein phosphatase 4 catalytic subunit antibody|Protein phosphatase X antibody|protein phosphatase X, catalytic subunit antibody|Serine/threonine protein phosphatase 4 catalytic subunit antibody|Serine/threonine-protein phosphatase 4 catalytic subunit antibody|Anti-PPP4C antibody [EPR19502] (ab195371)
SCBT cat No: sc-6118|sc-374106|

 

Name

PPX Monoclonal Antibody

Catalogue No.

STJ98539

Reactivity

Human, Mouse, Rat, Cow, Dog, Zebrafish

Specificity

PPX Monoclonal Antibody detects endogenous levels of PPX protein.

Immunogen

Purified recombinant human PPX protein fragments expressed in Ecoli

Host

Mouse

Applications

WB, IHC, IF

Recommended dilution

WB 1:1000-1:2000; IHC 1:500-1:1000; IF 1:100-1:500

Clonality

Monoclonal

Conjugation

Unconjugated

Formulation

PPX Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Concentration

1 mg/ml

Purification

PPX Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Serine/threonine-protein phosphatase 4 catalytic subunit antibody, PP4C antibody, Pp4 antibody, Protein phosphatase X antibody, PP-X antibody

Database links

Human UniProt/Swiss-Prot:P60510;Mouse UniPort/Swiss-Prot: P97470;Rat UniProt/Swiss-Port: Q5BJ92;Human Entrez Gene: 5531;Mouse Entrez Gene: 56420;Rat Entrez Gene: Rn.9173

Protein names

Serine/threonine-protein phosphatase 4 catalytic subunit , PP4C , Pp4 , Protein phosphatase X , PP-X

Protein function

Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin. / [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate. / Mn2+

Protein sequence and domain

Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.

Protein post-translational modifications

Methylation at the C-terminal Leu-307 is critical for interactions with regulatory subunits and functions in DNA repair.

Protein cellular localization

Cytoplasm / Nucleus / Cytoplasm > cytoskeleton > microtubule organizing center > centrosome

Research area

All research areas>Kinases and Phosphatases>PPX
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize PPX Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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