Mouse Monoclonal PR antibody [8A11H1] (STJ98333)

$379.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal PR antibody [8A11H1] (STJ98333)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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PGR antibody, NR3C3 antibody,|NR3C3 antibody|Nuclear receptor subfamily 3 group C member 3 antibody|PGR antibody|PR antibody|PRA antibody|PRB antibody|PRGR_HUMAN antibody|Progesterone receptor antibody|Progestin receptor form A antibody|Progestin receptor form B antibody|Anti-Progesterone Receptor antibody [Alpha PR6] – ChIP Grade (ab2765)
SCBT cat No: sc-57553|sc-56862|sc-32629|sc-377544|sc-11768|sc-16795|sc-12891|sc-130604|sc-377573|sc-101787|sc-31714|sc-6118|

 

Name

PR Monoclonal Antibody

Catalogue No.

STJ98333

Reactivity

Human

Specificity

PR Monoclonal Antibody detects endogenous levels of PR protein.

Immunogen

Purified recombinant fragment of PR (aa730-871) expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

PR Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

PR Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Progesterone receptor antibody, PR antibody, Nuclear receptor subfamily 3 group C member 3 antibody

Database links

Human UniProt/Swiss-Prot:P06401;Rat UniProt/Swiss-Port: Q63449;Human Entrez Gene: 5241;Mouse Entrez Gene: 18667;Rat Entrez Gene: Rn.10303

Protein names

Progesterone receptor , PR , Nuclear receptor subfamily 3 group C member 3

Protein function

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation. / Isoform A: inactive in stimulating c-Src/MAPK signaling on hormone stimulation. / Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.

Protein sequence and domain

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. / Belongs to the nuclear hormone receptor family. NR3 subfamily. / Contains 1 nuclear receptor DNA-binding domain.

Protein post-translational modifications

Phosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-294 occurs preferentially on isoform B, is highly hormone-dependent and modulates ubiquitination and sumoylation on Lys-388. Phosphorylation on Ser-102 and Ser-345 also requires induction by hormone. Basal phosphorylation on Ser-81, Ser-162, Ser-190 and Ser-400 is increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-400 also in the presence of EGF, heregulin, IGF, PMA and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation and transcriptional activity. Phosphorylation at Ser-162 and Ser-294, but not at Ser-190, is impaired during the G2/M phase of the cell cycle. Phosphorylation on Ser-345 by ERK1/2 MAPK is required for interaction with SP1. / Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-388, the main site of sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at Ser-294. / Ubiquitination is hormone-dependent and represses sumoylation on the same site. Promoted by MAPK-mediated phosphorylation on Ser-294. / Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation.

Protein cellular localization

Nucleus / Cytoplasm / Nucleus / Cytoplasm / Mitochondrion outer membrane

Research area

All research areas>Lymphocyte Signaling>PR
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus can customize PR Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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