Mouse Monoclonal PR antibody [8A11H1] (STJ98333)


Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal PR antibody [8A11H1] (STJ98333)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for PR Monoclonal Antibody.

Alternative names:

Check alternative names for the antibody


PGR antibody, NR3C3 antibody,|NR3C3 antibody|Nuclear receptor subfamily 3 group C member 3 antibody|PGR antibody|PR antibody|PRA antibody|PRB antibody|PRGR_HUMAN antibody|Progesterone receptor antibody|Progestin receptor form A antibody|Progestin receptor form B antibody|Anti-Progesterone Receptor antibody [Alpha PR6] – ChIP Grade (ab2765)
SCBT cat No: sc-57553|sc-56862|sc-32629|sc-377544|sc-11768|sc-16795|sc-12891|sc-130604|sc-377573|sc-101787|sc-31714|sc-6118|



PR Monoclonal Antibody

Catalogue No.





PR Monoclonal Antibody detects endogenous levels of PR protein.


Purified recombinant fragment of PR (aa730-871) expressed in E Coli





Recommended dilution

WB 1:500-1:2000; ELISA 1:10000








PR Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.


1 mg/ml


PR Antibody was purified using affinity purification.


-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Progesterone receptor antibody, PR antibody, Nuclear receptor subfamily 3 group C member 3 antibody

Database links

Human UniProt/Swiss-Prot:P06401;Rat UniProt/Swiss-Port: Q63449;Human Entrez Gene: 5241;Mouse Entrez Gene: 18667;Rat Entrez Gene: Rn.10303

Protein names

Progesterone receptor , PR , Nuclear receptor subfamily 3 group C member 3

Protein function

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation. / Isoform A: inactive in stimulating c-Src/MAPK signaling on hormone stimulation. / Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.

Protein sequence and domain

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. / Belongs to the nuclear hormone receptor family. NR3 subfamily. / Contains 1 nuclear receptor DNA-binding domain.

Protein post-translational modifications

Phosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-294 occurs preferentially on isoform B, is highly hormone-dependent and modulates ubiquitination and sumoylation on Lys-388. Phosphorylation on Ser-102 and Ser-345 also requires induction by hormone. Basal phosphorylation on Ser-81, Ser-162, Ser-190 and Ser-400 is increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-400 also in the presence of EGF, heregulin, IGF, PMA and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation and transcriptional activity. Phosphorylation at Ser-162 and Ser-294, but not at Ser-190, is impaired during the G2/M phase of the cell cycle. Phosphorylation on Ser-345 by ERK1/2 MAPK is required for interaction with SP1. / Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-388, the main site of sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at Ser-294. / Ubiquitination is hormone-dependent and represses sumoylation on the same site. Promoted by MAPK-mediated phosphorylation on Ser-294. / Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation.

Protein cellular localization

Nucleus / Cytoplasm / Nucleus / Cytoplasm / Mitochondrion outer membrane

Research area

All research areas>Lymphocyte Signaling>PR
(View all antibody categories related to Lymphocyte Signaling)


AntibodyPlus can customize PR Antibody according to your requirement, including bulk product size,etc. Please contact AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.


St John’s Laboratory Ltd.

Product type

Primary antibody


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