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Mouse Monoclonal PRMT6 antibody [4G2] (STJ98338)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
PRMT6 antibody, HRMT1L6 antibody,|ANM6_HUMAN antibody|Chromobox protein homolog 7 antibody|FLJ10559 antibody|FLJ51477 antibody|Heterogeneous nuclear ribonucleoprotein methyltransferase like protein 6 antibody|Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6 antibody|Histone-arginine N-methyltransferase PRMT6 antibody|HMT1 hnRNP methyltransferase like 6. antibody|HRMT1L6 antibody|OTTHUMP00000012633 antibody|PRMT 6 antibody|prmt6 antibody|Protein arginine methyltransferase 6 antibody|Protein arginine N methyltransferase 6 antibody|Protein arginine N-methyltransferase 6 antibody|Anti-PRMT6 antibody [EPR18500] (ab190902)
SCBT cat No: sc-271744|sc-134924|sc-365018|sc-55702|
PRMT6 Monoclonal Antibody
|Catalogue No.|| |
PRMT6 Monoclonal Antibody detects endogenous levels of PRMT6 protein.
Purified recombinant fragment of human PRMT6 expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
PRMT6 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
PRMT6 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Protein arginine N-methyltransferase 6 antibody, Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6 antibody, Histone-arginine N-methyltransferase PRMT6 antibody
|Protein names|| |
Protein arginine N-methyltransferase 6 , Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6 , Histone-arginine N-methyltransferase PRMT6
|Protein function|| |
Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 ‘Arg-2’ to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 ‘Lys-4’ (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 ‘Arg-3’ (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC). / 2 S-adenosyl-L-methionine + [protein]-L-arginine = 2 S-adenosyl-L-homocysteine + [protein]-N(omega),N(omega)-dimethyl-L-arginine. / 18.6 µM for AdoMet / 501 µM for WGGYSRGGYGGW peptide / 183.7 µM for WGGYSR(MMA)GGYGGW monomethylated peptide / 3.3 nmol/min/mg enzyme with AdoMet as substrate / 1.8 nmol/min/mg enzyme with WGGYSRGGYGGW peptide as substrate / 3.2 nmol/min/mg enzyme with WGGYSR(MMA)GGYGGW monomethylated peptide as substrate
|Protein tissue specificity|| |
Highly expressed in kidney and testis.
|Protein sequence and domain|| |
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT6 subfamily. / Contains 1 SAM-dependent MTase PRMT-type domain.
|Protein post-translational modifications|| |
Automethylation enhances its stability and antiretroviral activity.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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