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Mouse Monoclonal PSR antibody (STJ98543)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IF
Recommended dilution: WB 1:1000-1:2000; IF 1:100-1:500
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
JMJD6 antibody, KIAA0585 antibody, PTDSR antibody,|Apoptotic cell clearance receptor antibody|Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 antibody|Histone arginine demethylase JMJD6 antibody|JmjC domain-containing protein 6 antibody|JMJD 6 antibody|JMJD6 antibody|JMJD6_HUMAN antibody|Jumonji domain containing 6 antibody|Jumonji domain-containing protein 6 antibody|KIAA0585 antibody|Lysyl-hydroxylase JMJD6 antibody|Peptide-lysine 5-dioxygenase JMJD6 antibody|Phosphatidylserine receptor antibody|Protein PTDSR antibody|PSR antibody|PTDSR 1 antibody|PTDSR antibody|PTDSR1 antibody|Anti-JMJD6 antibody (ab134293)
SCBT cat No: sc-32740|sc-48405|sc-28349|sc-11366|sc-28348|
PSR Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat, Cow, Dog
PSR Monoclonal Antibody detects endogenous levels of PSR protein.
Purified recombinant human PSR (N-terminus) protein fragments expressed in Ecoli
|Recommended dilution|| |
WB 1:1000-1:2000; IF 1:100-1:500
PSR Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
PSR Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 antibody, Histone arginine demethylase JMJD6 antibody, JmjC domain-containing protein 6 antibody, Jumonji domain-containing protein 6 antibody, Lysyl-hydroxylase JMJD6 antibody, Peptide-lysine 5-dioxygenase JMJD6 antibody, Phosphatidylserine receptor antibody, Protein PTDSR antibody
|Protein names|| |
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 , Histone arginine demethylase JMJD6 , JmjC domain-containing protein 6 , Jumonji domain-containing protein 6 , Lysyl-hydroxylase JMJD6 , Peptide-lysine 5-dioxygenase JMJD6 , Phosphatidylserine receptor , Protein PTDSR
|Protein function|| |
Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at ‘Arg-2’ (H3R2me) and histone H4 at ‘Arg-3’ (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses. / Fe2+ / 39 µM for 2-oxoglutarate
|Protein tissue specificity|| |
Highly expressed in the heart, skeletal muscle and kidney. Expressed at moderate or low level in brain, placenta, lung, liver, pancreas, spleen, thymus, prostate, testis and ovary. Up-regulated in many patients with chronic pancreatitis. Expressed in nursing thymic epithelial cells.
|Protein sequence and domain|| |
The nuclear localization signal motifs are necessary and sufficient to target it into the nucleus. / Belongs to the JMJD6 family. / Contains 1 JmjC domain.
|Protein cellular localization|| |
Nucleus > nucleoplasm / Nucleus > nucleolus
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St John’s Laboratory Ltd.
|Product type|| |
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