Mouse Monoclonal PSR antibody (STJ98543)

$379.00

Reactivity: Human, Mouse, Rat, Cow, Dog
Applications: WB, IF
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal PSR antibody (STJ98543)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IF

Recommended dilution: WB 1:1000-1:2000; IF 1:100-1:500

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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JMJD6 antibody, KIAA0585 antibody, PTDSR antibody,|Apoptotic cell clearance receptor antibody|Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 antibody|Histone arginine demethylase JMJD6 antibody|JmjC domain-containing protein 6 antibody|JMJD 6 antibody|JMJD6 antibody|JMJD6_HUMAN antibody|Jumonji domain containing 6 antibody|Jumonji domain-containing protein 6 antibody|KIAA0585 antibody|Lysyl-hydroxylase JMJD6 antibody|Peptide-lysine 5-dioxygenase JMJD6 antibody|Phosphatidylserine receptor antibody|Protein PTDSR antibody|PSR antibody|PTDSR 1 antibody|PTDSR antibody|PTDSR1 antibody|Anti-JMJD6 antibody (ab134293)
SCBT cat No: sc-32740|sc-48405|sc-28349|sc-11366|sc-28348|

 

Name

PSR Monoclonal Antibody

Catalogue No.

STJ98543

Reactivity

Human, Mouse, Rat, Cow, Dog

Specificity

PSR Monoclonal Antibody detects endogenous levels of PSR protein.

Immunogen

Purified recombinant human PSR (N-terminus) protein fragments expressed in Ecoli

Host

Mouse

Applications

WB, IF

Recommended dilution

WB 1:1000-1:2000; IF 1:100-1:500

Clonality

Monoclonal

Conjugation

Unconjugated

Formulation

PSR Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Concentration

1 mg/ml

Purification

PSR Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 antibody, Histone arginine demethylase JMJD6 antibody, JmjC domain-containing protein 6 antibody, Jumonji domain-containing protein 6 antibody, Lysyl-hydroxylase JMJD6 antibody, Peptide-lysine 5-dioxygenase JMJD6 antibody, Phosphatidylserine receptor antibody, Protein PTDSR antibody

Database links

Human UniProt/Swiss-Prot:Q6NYC1;Mouse UniPort/Swiss-Prot: Q9ERI5;Rat UniProt/Swiss-Port: Q6AYK2;Human Entrez Gene: 23210;Mouse Entrez Gene: 107817;Rat Entrez Gene: Rn.19923

Protein names

Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 , Histone arginine demethylase JMJD6 , JmjC domain-containing protein 6 , Jumonji domain-containing protein 6 , Lysyl-hydroxylase JMJD6 , Peptide-lysine 5-dioxygenase JMJD6 , Phosphatidylserine receptor , Protein PTDSR

Protein function

Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at ‘Arg-2’ (H3R2me) and histone H4 at ‘Arg-3’ (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses. / Fe2+ / 39 µM for 2-oxoglutarate

Protein tissue specificity

Highly expressed in the heart, skeletal muscle and kidney. Expressed at moderate or low level in brain, placenta, lung, liver, pancreas, spleen, thymus, prostate, testis and ovary. Up-regulated in many patients with chronic pancreatitis. Expressed in nursing thymic epithelial cells.

Protein sequence and domain

The nuclear localization signal motifs are necessary and sufficient to target it into the nucleus. / Belongs to the JMJD6 family. / Contains 1 JmjC domain.

Protein cellular localization

Nucleus > nucleoplasm / Nucleus > nucleolus

Research area

All research areas>Membrane Receptors>PSR
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize PSR Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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