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Mouse Monoclonal Rab 10 antibody [4E2] (STJ98346)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
RAB10 antibody,|GTP binding protein RAB10 antibody||Anti-RAB10 antibody [4E2] (ab104859)
SCBT cat No: sc-101429|sc-6564|
Rab 10 Monoclonal Antibody
|Catalogue No.|| |
Rab 10 Monoclonal Antibody detects endogenous levels of Rab 10 protein.
Purified recombinant fragment of human Rab 10 expressed in E Coli
WB, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000
Rab 10 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
Rab 10 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Ras-related protein Rab-10 antibody
|Protein names|| |
Ras-related protein Rab-10
|Protein function|| |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. Plays also a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and epithelial cells. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane while in epithelial cells, it regulates transport from the Golgi to the basolateral membrane. Moreover, may play a role in the basolateral recycling pathway and in phagosome maturation. According to PubMed:23263280, may play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion. / Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP) (By similarity). That Rab is activated by the DENND4C guanine exchange factor (GEF).
|Protein sequence and domain|| |
Belongs to the small GTPase superfamily. Rab family.
|Protein cellular localization|| |
Cytoplasmic vesicle membrane / Golgi apparatus membrane / Golgi apparatus > trans-Golgi network membrane / Endosome membrane / Recycling endosome membrane / Cytoplasmic vesicle > phagosome membrane / Cell projection > cilium / Endoplasmic reticulum membrane
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St John’s Laboratory Ltd.
|Product type|| |
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