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Mouse Monoclonal Raf-B antibody [1H12F1; 1H12G10; 1F12F11C9] (STJ98350)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
BRAF antibody, BRAF1 antibody, RAFB1 antibody,|FLJ95109 antibody|94 kDa B raf protein antibody|B raf 1 antibody|B Raf proto oncogene serine threonine protein kinase antibody|B Raf proto oncogene, serine/threonine kinase antibody|B RAF1 antibody|B-Raf proto-oncogene serine/threonine-protein kinase (p94) antibody|BRAF 1 antibody|BRAF antibody|BRAF_HUMAN antibody|BRAF1 antibody|cRmil antibody|MGC126806 antibody|MGC138284 antibody|Murine sarcoma viral (v-raf) oncogene homolog B1 antibody|Murine sarcoma viral v raf oncogene homolog B1 antibody|NS7 antibody|Oncogen BRAF antibody|oncogene BRAF1 antibody|p94 antibody|Proto-oncogene B-Raf antibody|Proto-oncogene c-Rmil antibody|RAFB 1 antibody|RAFB1 antibody|RMIL antibody|Serine/threonine-protein kinase B-raf antibody|v raf murine sarcoma viral oncogene homolog B antibody|v raf murine sarcoma viral oncogene homolog B1 antibody|v-Raf murine sarcoma viral oncogene homolog B1 antibody|Anti-B Raf antibody [EP152Y] (ab33899)
SCBT cat No: sc-28006|sc-81705|sc-46667|sc-25419|sc-8251|sc-376451|
Raf-B Monoclonal Antibody
|Catalogue No.|| |
Raf-B Monoclonal Antibody detects endogenous levels of Raf-B protein.
Purified recombinant fragment of Raf-B expressed in E Coli
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
Raf-B Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
Raf-B Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Serine/threonine-protein kinase B-raf antibody, Proto-oncogene B-Raf antibody, p94 antibody, v-Raf murine sarcoma viral oncogene homolog B1 antibody
|Protein names|| |
Serine/threonine-protein kinase B-raf , Proto-oncogene B-Raf , p94 , v-Raf murine sarcoma viral oncogene homolog B1
|Protein function|| |
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway. / ATP + a protein = ADP + a phosphoprotein. / Zn2+ / Activity is increased by EGF and HGF.
|Protein tissue specificity|| |
Brain and testis.
|Involvement in disease|| |
Note: Defects in BRAF are found in a wide range of cancers. .; Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. . Note: The disease may be caused by mutations affecting the gene represented in this entry.; Lung cancer (LNCR) [MIM:211980]: A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. . Note: The gene represented in this entry is involved in disease pathogenesis.; Familial non-Hodgkin lymphoma (NHL) [MIM:605027]: Cancer that starts in cells of the lymph system, which is part of the body’s immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss. . Note: The gene represented in this entry is involved in disease pathogenesis.; Cardiofaciocutaneous syndrome 1 (CFC1) [MIM:115150]: A multiple congenital anomaly disorder characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Noonan syndrome 7 (NS7) [MIM:613706]: A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. . Note: The disease is caused by mutations affecting the gene represented in this entry.; LEOPARD syndrome 3 (LPRD3) [MIM:613707]: A disorder characterized by lentigines, electrocardiographic conduction abnormalities, ocular hypertelorism, pulmonic stenosis, abnormalities of genitalia, retardation of growth, and sensorineural deafness. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Note: A chromosomal aberration involving BRAF is found in pilocytic astrocytomas. A tandem duplication of 2 Mb at 7q34 leads to the expression of a KIAA1549-BRAF fusion protein with a constitutive kinase activity and inducing cell transformation. .
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. / Contains 1 phorbol-ester/DAG-type zinc finger. / Contains 1 protein kinase domain. / Contains 1 RBD (Ras-binding) domain.
|Protein post-translational modifications|| |
Phosphorylation at Ser-365 by SGK1 inhibits its activity. / Methylation at Arg-671 decreases stability and kinase activity. / Ubiquitinated by RNF149; which leads to proteasomal degradation. Polyubiquitinated at Lys-578 in response to EGF.
|Protein cellular localization|| |
Nucleus / Cytoplasm / Cell membrane
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St John’s Laboratory Ltd.
|Product type|| |
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