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Mouse Monoclonal RASSF1 antibody (STJ98546)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB
Recommended dilution: WB 1:1000-1:2000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
RASSF1 antibody, RDA32 antibody,|Ras association domain containing protein 1 antibody|Ras association domain family 1 antibody|Ras association domain family protein 1 antibody|Ras association domain-containing protein 1 antibody|RASF1_HUMAN antibody|RASSF 1a antibody|Rassf1 antibody|RASSF1A antibody|RASSF1A isoform antibody|Tumor suppressor protein RDA32 antibody|Anti-RASSF1a antibody [3F3] (ab23950)
SCBT cat No: sc-58470|sc-18724|sc-28563|sc-18722|
RASSF1 Monoclonal Antibody
|Catalogue No.|| |
RASSF1 Monoclonal Antibody detects endogenous levels of RASSF1 protein.
Purified recombinant human RASSF1 protein fragments expressed in Ecoli
|Recommended dilution|| |
RASSF1 Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
RASSF1 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Ras association domain-containing protein 1 antibody
|Protein names|| |
Ras association domain-containing protein 1
|Protein function|| |
Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.
|Protein tissue specificity|| |
Isoform A and isoform C are ubiquitously expressed in all tissues tested, however isoform A is absent in many corresponding cancer cell lines. Isoform B is mainly expressed in hematopoietic cells.
|Protein sequence and domain|| |
Contains 1 phorbol-ester/DAG-type zinc finger. / Contains 1 Ras-associating domain. / Contains 1 SARAH domain.
|Protein cellular localization|| |
Cytoplasm > cytoskeleton / Cytoplasm > cytoskeleton > microtubule organizing center > centrosome / Cytoplasm > cytoskeleton > spindle / Cytoplasm > cytoskeleton > spindle pole / Nucleus / Nucleus
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St John’s Laboratory Ltd.
|Product type|| |
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