Mouse Monoclonal RASSF1 antibody (STJ98546)

$379.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal RASSF1 antibody (STJ98546)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB

Recommended dilution: WB 1:1000-1:2000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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RASSF1 antibody, RDA32 antibody,|Ras association domain containing protein 1 antibody|Ras association domain family 1 antibody|Ras association domain family protein 1 antibody|Ras association domain-containing protein 1 antibody|RASF1_HUMAN antibody|RASSF 1a antibody|Rassf1 antibody|RASSF1A antibody|RASSF1A isoform antibody|Tumor suppressor protein RDA32 antibody|Anti-RASSF1a antibody [3F3] (ab23950)
SCBT cat No: sc-58470|sc-18724|sc-28563|sc-18722|

 

Name

RASSF1 Monoclonal Antibody

Catalogue No.

STJ98546

Reactivity

Human

Specificity

RASSF1 Monoclonal Antibody detects endogenous levels of RASSF1 protein.

Immunogen

Purified recombinant human RASSF1 protein fragments expressed in Ecoli

Host

Mouse

Applications

WB

Recommended dilution

WB 1:1000-1:2000

Clonality

Monoclonal

Conjugation

Unconjugated

Formulation

RASSF1 Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Concentration

1 mg/ml

Purification

RASSF1 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Ras association domain-containing protein 1 antibody

Database links

Human UniProt/Swiss-Prot:Q9NS23;Mouse UniPort/Swiss-Prot: Q99MK9;Rat UniProt/Swiss-Port: Q68FW0;Human Entrez Gene: 11186;Mouse Entrez Gene: 56289;Rat Entrez Gene: Rn.83042

Protein names

Ras association domain-containing protein 1

Protein function

Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.

Protein tissue specificity

Isoform A and isoform C are ubiquitously expressed in all tissues tested, however isoform A is absent in many corresponding cancer cell lines. Isoform B is mainly expressed in hematopoietic cells.

Protein sequence and domain

Contains 1 phorbol-ester/DAG-type zinc finger. / Contains 1 Ras-associating domain. / Contains 1 SARAH domain.

Protein cellular localization

Cytoplasm > cytoskeleton / Cytoplasm > cytoskeleton > microtubule organizing center > centrosome / Cytoplasm > cytoskeleton > spindle / Cytoplasm > cytoskeleton > spindle pole / Nucleus / Nucleus

Research area

All research areas>GDP/GTP Binding Proteins>RASSF
(View all antibody categories related to GDP/GTP Binding Proteins)

Note

AntibodyPlus can customize RASSF1 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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