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Mouse Monoclonal Rictor antibody [4H5] (STJ98363)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
RICTOR antibody, KIAA1999 antibody,|AVO3 antibody|AVO3 homolog antibody|DKFZp686B11164 antibody|hAVO3 antibody|KIAA1999 antibody|Likely ortholog of mouse TORC2 specific protein AVO3 (S. cerevisiae) antibody|mAVO3 antibody|MGC39830 antibody|PIA antibody|Pianissimo antibody|Rapamycin insensitive companion of mTOR antibody|Rapamycin-insensitive companion of mTOR antibody|Rictor antibody|RICTR antibody|RICTR_HUMAN antibody|RPTOR independent companion of MTOR complex 2 antibody|TORC2 specific protein AVO3 antibody|Anti-RICTOR antibody (ab70374)
SCBT cat No: sc-81538|sc-271081|sc-99004|sc-50678|sc-130865|
Rictor Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Monkey
Rictor Monoclonal Antibody detects endogenous levels of Rictor protein.
Purified recombinant fragment of human Rictor expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
Rictor Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
Rictor Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Rapamycin-insensitive companion of mTOR antibody, AVO3 homolog antibody, hAVO3 antibody
|Protein names|| |
Rapamycin-insensitive companion of mTOR , AVO3 homolog , hAVO3
|Protein function|| |
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 ‘Ser-473’ phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on ‘Thr-308’ by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at ‘Ser-422’. mTORC2 also modulates the phosphorylation of PRKCA on ‘Ser-657’. Plays an essential role in embryonic growth and development.
|Protein sequence and domain|| |
Belongs to the RICTOR family.
|Protein post-translational modifications|| |
Phosphorylated by MTOR; when part of mTORC2. Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits mTORC2 and AKT1 signaling.
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St John’s Laboratory Ltd.
|Product type|| |
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