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Mouse Monoclonal Ron antibody [1B5A9] (STJ98364)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
MST1R antibody, PTK8 antibody, RON antibody,|Macrophage stimulating 1 receptor antibody|Macrophage stimulating protein receptor alpha chain antibody|MACROPHAGE STIMULATING PROTEIN RECEPTOR antibody|Macrophage stimulating protein receptor beta chain antibody|Macrophage-Stimulating 1 Receptor (MST1R) antibody|Macrophage-stimulating protein receptor beta chain antibody|MSP receptor antibody|Mst1r antibody|MST1R variant RON30 antibody|MST1R variant RON62 antibody|p185 RON antibody|p185-Ron antibody|Protein-tyrosine kinase 8 antibody|PTK 8 antibody|ptk8 antibody|PTK8 protein tyrosine kinase 8 antibody|Recepteur d¡¯origine nantais (RON) antibody|RON antibody|RON protein tyrosine kinase antibody|RON variant E2E3 antibody|RON_HUMAN antibody|Soluble RON variant 1 antibody|Soluble RON variant 2 antibody|Soluble RON variant 3 antibody|Soluble RON variant 4 antibody|Stem cell derived tyrosine kinase antibody|Anti-RON antibody [EP1132Y] (ab52927)
SCBT cat No: sc-22193|sc-16838|sc-16840|sc-365664|sc-393723|sc-68366|sc-67794|sc-68367|sc-393505|sc-74860|sc-393103|
Ron Monoclonal Antibody
|Catalogue No.|| |
Ron Monoclonal Antibody detects endogenous levels of Ron protein.
Purified recombinant fragment of human Ron (aa210-320) expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
Ron Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
Ron Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Macrophage-stimulating protein receptor antibody, MSP receptor antibody, CDw136 antibody, Protein-tyrosine kinase 8 antibody, p185-Ron antibody, CD antigen CD136 antibody
|Protein names|| |
Macrophage-stimulating protein receptor , MSP receptor , CDw136 , Protein-tyrosine kinase 8 , p185-Ron , CD antigen CD136
|Protein function|| |
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. / In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity.
|Protein tissue specificity|| |
Expressed in colon, skin, lung and bone marrow.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Tyr protein kinase family. / Contains 3 IPT/TIG domains. / Contains 1 protein kinase domain. / Contains 1 Sema domain.
|Protein post-translational modifications|| |
Proteolytic processing yields the two subunits. / Autophosphorylated in response to ligand binding on Tyr-1238 and Tyr-1239 in the kinase domain leading to further phosphorylation of Tyr-1353 and Tyr-1360 in the C-terminal multifunctional docking site. / Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation.
|Protein cellular localization|| |
Membrane; Single-pass type I membrane protein
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St John’s Laboratory Ltd.
|Product type|| |
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