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Mouse Monoclonal Rsk-2 antibody [4E10] (STJ98367)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IF, FC, ELISA
Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
RPS6KA3 antibody, ISPK1 antibody, MAPKAPK1B antibody, RSK2 antibody,|90 kDa ribosomal protein S6 kinase 3 antibody|CLS antibody|HU 3 antibody|HU2 antibody|HU3 antibody|Insulin stimulated protein kinase 1 antibody|Insulin-stimulated protein kinase 1 antibody|ISPK-1 antibody|ISPK1 antibody|KS6A3_HUMAN antibody|MAP kinase activated protein kinase 1b antibody|MAP kinase-activated protein kinase 1b antibody|MAPK activated protein kinase 1b antibody|MAPK-activated protein kinase 1b antibody|MAPKAP kinase 1b antibody|MAPKAPK 1b antibody|MAPKAPK-1b antibody|MAPKAPK1B antibody|Mental retardation, X linked 19 antibody|MRX19 antibody|OTTHUMP00000023036 antibody|p90 RSK2 antibody|p90 RSK3 antibody|p90-RSK 3 antibody|p90RSK3 antibody|pp90RSK2 antibody|Ribosomal protein S6 kinase 90kDa polypeptide 3 antibody|Ribosomal protein S6 kinase alpha 3 antibody|Ribosomal protein S6 kinase alpha-3 antibody|Ribosomal protein s6 kinase ii alpha 2 antibody|Ribosomal S6 kinase 2 antibody|Rps6ka3 antibody|RSK antibody|RSK-2 antibody|RSK2 antibody|S6 kinase 2 antibody|S6K alpha3 antibody|S6K-alpha-3 antibody|Anti-Rsk 2 / MAPKAP Kinase 1b antibody [Y83] (ab32133)
SCBT cat No: sc-74575|
Rsk-2 Monoclonal Antibody
|Catalogue No.|| |
Rsk-2 Monoclonal Antibody detects endogenous levels of Rsk-2 protein.
Purified recombinant fragment of human Rsk-2 expressed in E Coli
WB, IF, FC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
Rsk-2 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
Rsk-2 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Ribosomal protein S6 kinase alpha-3 antibody, S6K-alpha-3 antibody, 90 kDa ribosomal protein S6 kinase 3 antibody, p90-RSK 3 antibody, p90RSK3 antibody, Insulin-stimulated protein kinase 1 antibody, ISPK-1 antibody, MAP kinase-activated protein kinase 1b antibody, MAPK-activated protein kinase 1b antibody, MAPKAP kinase 1b antibody, MAPKAPK-1b antibody, Ribosomal S6 kinase 2 antibody, RSK-2 antibody, pp90RSK2 antibody
|Protein names|| |
Ribosomal protein S6 kinase alpha-3 , S6K-alpha-3 , 90 kDa ribosomal protein S6 kinase 3 , p90-RSK 3 , p90RSK3 , Insulin-stimulated protein kinase 1 , ISPK-1 , MAP kinase-activated protein kinase 1b , MAPK-activated protein kinase 1b , MAPKAP kinase 1b , MAPKAPK-1b , Ribosomal S6 kinase 2 , RSK-2 , pp90RSK2
|Protein function|| |
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at ‘Ser-10’, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at ‘Ser-9’ and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at ‘Ser-1798’, which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3. Phosphorylates DAPK1. / ATP + a protein = ADP + a phosphoprotein. / Mg2+ / Upon extracellular signal or mitogen stimulation, phosphorylated at Thr-577 in the C-terminal kinase domain (CTKD) by MAPK1/ERK2 and MAPK3/ERK1. The activated CTKD then autophosphorylates Ser-386, allowing binding of PDPK1, which in turn phosphorylates Ser-227 in the N-terminal kinase domain (NTDK) leading to the full activation of the protein and subsequent phosphorylation of the substrates by the NTKD.
|Protein tissue specificity|| |
Expressed in many tissues, highest levels in skeletal muscle.
|Involvement in disease|| |
Coffin-Lowry syndrome (CLS) [MIM:303600]: A X-linked mental retardation associated with facial and digital dysmorphisms, progressive skeletal malformations, growth retardation, hearing deficit and paroxysmal movement disorders. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Mental retardation, X-linked 19 (MRX19) [MIM:300844]: A non-syndromic form of mild to moderate mental retardation. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. / Contains 1 AGC-kinase C-terminal domain. / Contains 2 protein kinase domains.
|Protein post-translational modifications|| |
Activated by phosphorylation at Ser-227 by PDPK1. Autophosphorylated on Ser-386, as part of the activation process. May be phosphorylated at Thr-365 and Ser-369 by MAPK1/ERK2 and MAPK3/ERK1. Can also be activated via phosphorylation at Ser-386 by MAPKAPK2. / N-terminal myristoylation results in an activated kinase in the absence of added growth factors.
|Protein cellular localization|| |
Nucleus / Cytoplasm
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St John’s Laboratory Ltd.
|Product type|| |
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