Mouse Monoclonal SAF-B antibody (STJ98547)

$379.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal SAF-B antibody (STJ98547)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB

Recommended dilution: WB 1:1000-1:2000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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SAFB antibody, HAP antibody, HET antibody, SAFB1 antibody,|DKFZp779C1727 antibody|glutathione S transferase fusion protein antibody|HAP antibody|HET antibody|HSP27 ERE TATA binding protein antibody|HSP27 ERE-TATA-binding protein antibody|HSP27 estrogen response element-TATA box-binding protein antibody|SAF B antibody|SAF-B antibody|SAF-B1 antibody|SAFB 1 antibody|SAFB antibody|SAFB1 antibody|SAFB1_HUMAN antibody|Scaffold attachment factor B1 antibody|Anti-SAFB antibody [EPR13588] – C-terminal (ab187650)
SCBT cat No: sc-393455|sc-514963|sc-393689|

 

Name

SAF-B Monoclonal Antibody

Catalogue No.

STJ98547

Reactivity

Human

Specificity

SAF-B Monoclonal Antibody detects endogenous levels of SAF-B protein.

Immunogen

Purified recombinant human SAF-B protein fragments expressed in Ecoli

Host

Mouse

Applications

WB

Recommended dilution

WB 1:1000-1:2000

Clonality

Monoclonal

Conjugation

Unconjugated

Formulation

SAF-B Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Concentration

1 mg/ml

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Scaffold attachment factor B1 antibody, SAF-B antibody, SAF-B1 antibody, HSP27 estrogen response element-TATA box-binding protein antibody, HSP27 ERE-TATA-binding protein antibody

Database links

Human UniProt/Swiss-Prot:Q15424;Mouse UniPort/Swiss-Prot: D3YXK2;Rat UniProt/Swiss-Port: A0A0G2JZI0;Human Entrez Gene: 6294;Mouse Entrez Gene: 224903;Rat Entrez Gene: Rn.88640

Protein names

Scaffold attachment factor B1 , SAF-B , SAF-B1 , HSP27 estrogen response element-TATA box-binding protein , HSP27 ERE-TATA-binding protein

Protein function

Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a ‘transcriptosomal’ complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). Can inhibit cell proliferation.

Protein tissue specificity

Ubiquitous. Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines.

Protein sequence and domain

Contains 1 RRM (RNA recognition motif) domain. / Contains 1 SAP domain.

Protein post-translational modifications

Sumoylated by PIAS1 with SUMO1 and SUMO2/3, desumoylated by SENP1. Sumoylation is required for transcriptional repressor activity.

Protein cellular localization

Nucleus

Research area

All research areas>Transcription Regulators>SAF-B
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize SAF-B Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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