Mouse Monoclonal Skp2 p45 antibody [6G9D10] (STJ98381)

$379.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Skp2 p45 antibody [6G9D10] (STJ98381)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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SKP2 antibody, FBXL1 antibody,|CDK2/Cyclin A associated protein p45 antibody|Cyclin A/CDK2 associated protein p45 antibody|Cyclin-A/CDK2-associated protein p45 antibody|F box protein Skp2 antibody|F box/LRR repeat protein 1 antibody|F-box protein Skp2 antibody|F-box/LRR-repeat protein 1 antibody|FBL 1 antibody|FBL1 antibody|FBXL 1 antibody|FBXL1 antibody|FLB 1 antibody|FLB1 antibody|MGC1366 antibody|p45 antibody|p45skp2 antibody|S phase kinase associated protein 2 (p45) antibody|S phase kinase associated protein 2 antibody|S-phase kinase-associated protein 2 antibody|S-phase kinase-associated protein 2 E3 ubiquitin protein ligase antibody|SKP 2 antibody|Skp2 antibody|SKP2_HUMAN antibody|Anti-SKP2 antibody (ab68455)
SCBT cat No: To be updated

 

Name

Skp2 p45 Monoclonal Antibody

Catalogue No.

STJ98381

Reactivity

Human

Specificity

Skp2 p45 Monoclonal Antibody detects endogenous levels of Skp2 p45 protein.

Immunogen

Purified recombinant fragment of Skp2 p45 (aa1-130) expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

Skp2 p45 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

Skp2 p45 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

S-phase kinase-associated protein 2 antibody, Cyclin-A/CDK2-associated protein p45 antibody, F-box protein Skp2 antibody, F-box/LRR-repeat protein 1 antibody, p45skp2 antibody

Database links

Human UniProt/Swiss-Prot:Q13309;Mouse UniPort/Swiss-Prot: Q9Z0Z3;Rat UniProt/Swiss-Port: B2GUZ0;Human Entrez Gene: 6502;Mouse Entrez Gene: 27401;Rat Entrez Gene: Rn.154278

Protein names

S-phase kinase-associated protein 2 , Cyclin-A/CDK2-associated protein p45 , F-box protein Skp2 , F-box/LRR-repeat protein 1 , p45skp2

Protein function

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration. /

Protein sequence and domain

Contains 1 F-box domain. / Contains 10 LRR (leucine-rich) repeats.

Protein post-translational modifications

Ubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Deubiquitinated by USP13. / Acetylation at Lys-68 and Lys-71 increases stability through impairment of APC/C-mediated proteolysis and promotes cytoplasmic retention. Deacetylated by SIRT3.

Protein cellular localization

Cytoplasm / Nucleus

Research area

All research areas>Cell Cycle Proteins>Skp
(View all antibody categories related to Cell Cycle Proteins)

Note

AntibodyPlus can customize Skp2 p45 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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