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Mouse Monoclonal Skp2 p45 antibody [6G9D10] (STJ98381)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
SKP2 antibody, FBXL1 antibody,|CDK2/Cyclin A associated protein p45 antibody|Cyclin A/CDK2 associated protein p45 antibody|Cyclin-A/CDK2-associated protein p45 antibody|F box protein Skp2 antibody|F box/LRR repeat protein 1 antibody|F-box protein Skp2 antibody|F-box/LRR-repeat protein 1 antibody|FBL 1 antibody|FBL1 antibody|FBXL 1 antibody|FBXL1 antibody|FLB 1 antibody|FLB1 antibody|MGC1366 antibody|p45 antibody|p45skp2 antibody|S phase kinase associated protein 2 (p45) antibody|S phase kinase associated protein 2 antibody|S-phase kinase-associated protein 2 antibody|S-phase kinase-associated protein 2 E3 ubiquitin protein ligase antibody|SKP 2 antibody|Skp2 antibody|SKP2_HUMAN antibody|Anti-SKP2 antibody (ab68455)
SCBT cat No: To be updated
Skp2 p45 Monoclonal Antibody
|Catalogue No.|| |
Skp2 p45 Monoclonal Antibody detects endogenous levels of Skp2 p45 protein.
Purified recombinant fragment of Skp2 p45 (aa1-130) expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
Skp2 p45 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
Skp2 p45 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
S-phase kinase-associated protein 2 antibody, Cyclin-A/CDK2-associated protein p45 antibody, F-box protein Skp2 antibody, F-box/LRR-repeat protein 1 antibody, p45skp2 antibody
|Protein names|| |
S-phase kinase-associated protein 2 , Cyclin-A/CDK2-associated protein p45 , F-box protein Skp2 , F-box/LRR-repeat protein 1 , p45skp2
|Protein function|| |
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration. /
|Protein sequence and domain|| |
Contains 1 F-box domain. / Contains 10 LRR (leucine-rich) repeats.
|Protein post-translational modifications|| |
Ubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Deubiquitinated by USP13. / Acetylation at Lys-68 and Lys-71 increases stability through impairment of APC/C-mediated proteolysis and promotes cytoplasmic retention. Deacetylated by SIRT3.
|Protein cellular localization|| |
Cytoplasm / Nucleus
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St John’s Laboratory Ltd.
|Product type|| |
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