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Mouse Monoclonal SLUG antibody [2H5] (STJ98382)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for SLUG Monoclonal Antibody.
Check alternative names for the antibodyExpand
SNAI2 antibody, SLUG antibody, SLUGH antibody,|MGC10182 antibody|Neural crest transcription factor Slug antibody|Protein snail homolog 2 antibody|Slug (chicken homolog) zinc finger protein antibody|Slug homolog zinc finger protein antibody|Slug zinc finger protein antibody|SLUGH antibody|SLUGH 1 antibody|SLUGH1 antibody|SNAI 2 antibody|Snai2 antibody|SNAI2_HUMAN antibody|Snail 2 antibody|Snail homolog 2 antibody|Snail2 antibody|WS 2D antibody|WS2D antibody|Zinc finger protein SLUG antibody|Zinc finger protein SNAI2 antibody|Anti-SLUG antibody (ab27568)
SCBT cat No: To be updated
SLUG Monoclonal Antibody
|Catalogue No.|| |
SLUG Monoclonal Antibody detects endogenous levels of SLUG protein.
Purified recombinant fragment of human SLUG expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
SLUG Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
SLUG Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Zinc finger protein SNAI2 antibody, Neural crest transcription factor Slug antibody, Protein snail homolog 2 antibody
|Protein names|| |
Zinc finger protein SNAI2 , Neural crest transcription factor Slug , Protein snail homolog 2
|Protein function|| |
Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.
|Protein tissue specificity|| |
Expressed in most adult human tissues, including spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not detected in peripheral blood leukocyte. Expressed in the dermis and in all layers of the epidermis, with high levels of expression in the basal layers (at protein level). Expressed in osteoblasts (at protein level). Expressed in mesenchymal stem cells (at protein level). Expressed in breast tumor cells (at protein level).
|Involvement in disease|| |
Waardenburg syndrome 2D (WS2D) [MIM:608890]: WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Piebald trait (PBT) [MIM:172800]: Autosomal dominant genetic developmental abnormality of pigmentation characterized by congenital patches of white skin and hair that lack melanocytes. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Repression activity depends on the C-terminal DNA-binding zinc fingers and on the N-terminal repression domain. / Belongs to the snail C2H2-type zinc-finger protein family. / Contains 5 C2H2-type zinc fingers.
|Protein post-translational modifications|| |
GSK3B-mediated phosphorylation results in cytoplasmic localization and degradation.
|Protein cellular localization|| |
Nucleus / Cytoplasm
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St John’s Laboratory Ltd.
|Product type|| |
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