Mouse Monoclonal SLUG antibody [2H5] (STJ98382)

$379.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal SLUG antibody [2H5] (STJ98382)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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SNAI2 antibody, SLUG antibody, SLUGH antibody,|MGC10182 antibody|Neural crest transcription factor Slug antibody|Protein snail homolog 2 antibody|Slug (chicken homolog) zinc finger protein antibody|Slug homolog zinc finger protein antibody|Slug zinc finger protein antibody|SLUGH antibody|SLUGH 1 antibody|SLUGH1 antibody|SNAI 2 antibody|Snai2 antibody|SNAI2_HUMAN antibody|Snail 2 antibody|Snail homolog 2 antibody|Snail2 antibody|WS 2D antibody|WS2D antibody|Zinc finger protein SLUG antibody|Zinc finger protein SNAI2 antibody|Anti-SLUG antibody (ab27568)
SCBT cat No: To be updated

 

Name

SLUG Monoclonal Antibody

Catalogue No.

STJ98382

Reactivity

Human

Specificity

SLUG Monoclonal Antibody detects endogenous levels of SLUG protein.

Immunogen

Purified recombinant fragment of human SLUG expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

SLUG Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

SLUG Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Zinc finger protein SNAI2 antibody, Neural crest transcription factor Slug antibody, Protein snail homolog 2 antibody

Database links

Human UniProt/Swiss-Prot:O43623;Mouse UniPort/Swiss-Prot: P97469;Rat UniProt/Swiss-Port: O08954;Human Entrez Gene: 6591;Mouse Entrez Gene: 20583;Rat Entrez Gene: Rn.43117

Protein names

Zinc finger protein SNAI2 , Neural crest transcription factor Slug , Protein snail homolog 2

Protein function

Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.

Protein tissue specificity

Expressed in most adult human tissues, including spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not detected in peripheral blood leukocyte. Expressed in the dermis and in all layers of the epidermis, with high levels of expression in the basal layers (at protein level). Expressed in osteoblasts (at protein level). Expressed in mesenchymal stem cells (at protein level). Expressed in breast tumor cells (at protein level).

Involvement in disease

Waardenburg syndrome 2D (WS2D) [MIM:608890]: WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Piebald trait (PBT) [MIM:172800]: Autosomal dominant genetic developmental abnormality of pigmentation characterized by congenital patches of white skin and hair that lack melanocytes. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Repression activity depends on the C-terminal DNA-binding zinc fingers and on the N-terminal repression domain. / Belongs to the snail C2H2-type zinc-finger protein family. / Contains 5 C2H2-type zinc fingers.

Protein post-translational modifications

GSK3B-mediated phosphorylation results in cytoplasmic localization and degradation.

Protein cellular localization

Nucleus / Cytoplasm

Research area

All research areas>Transcription Regulators>SLUG
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize SLUG Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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