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Mouse Monoclonal Smad6 antibody [5H3] (STJ98387)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
SMAD6 antibody, MADH6 antibody,|hSMAD6 antibody|MAD homolog 6 antibody|MADH6 antibody|MADH7 antibody|Mothers against decapentaplegic homolog 6 antibody|Mothers against DPP homolog 6 antibody|SMAD 6 antibody|SMAD family member 6 antibody|SMAD mothers against DPP homolog 6 antibody|Smad6 antibody|SMAD6_HUMAN antibody|Anti-SMAD6 antibody (ab13727)
SCBT cat No: To be updated
Smad6 Monoclonal Antibody
|Catalogue No.|| |
Smad6 Monoclonal Antibody detects endogenous levels of Smad6 protein.
Purified recombinant fragment of human Smad6 expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
Smad6 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
Smad6 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Mothers against decapentaplegic homolog 6 antibody, MAD homolog 6 antibody, Mothers against DPP homolog 6 antibody, SMAD family member 6 antibody, SMAD 6 antibody, Smad6 antibody, hSMAD6 antibody
|Protein names|| |
Mothers against decapentaplegic homolog 6 , MAD homolog 6 , Mothers against DPP homolog 6 , SMAD family member 6 , SMAD 6 , Smad6 , hSMAD6
|Protein function|| |
Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.
|Protein tissue specificity|| |
Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
|Involvement in disease|| |
Aortic valve disease 2 (AOVD2) [MIM:614823]: A common defect in the aortic valve in which two rather than three leaflets are present. It is often associated with aortic valve calcification, stenosis and insufficiency. In extreme cases, the blood flow may be so restricted that the left ventricle fails to grow, resulting in hypoplastic left heart syndrome. . Note: The disease is caused by mutations affecting the gene represented in this entry. SMAD6 variants may contribute to increased risk of congenital cardiovascular malformations (CVM). CVM is a major cause of mortality and morbidity in childhood. In most sporadic cases that cannot be attributed to particular malformation syndromes or teratogenic exposures, there remains a substantial excess familial risk, indicating a significant genetic contribution to disease susceptibility (PubMed:22275001). .
|Protein sequence and domain|| |
Belongs to the dwarfin/SMAD family. / Contains 1 MH1 (MAD homology 1) domain. / Contains 1 MH2 (MAD homology 2) domain.
|Protein post-translational modifications|| |
Phosphorylated by BMP type 1 receptor kinase and by PRKX. / Ubiquitinated by WWP1 (By similarity). Monoubiquitinated at Lys-173 by the E2/E3 hybrid ubiquitin-protein ligase UBE2O, leading to reduced binding affinity for the activated BMP type I receptor ACVR1/ALK2, thereby enhancing BMP7 and regulating adipocyte differentiation. / Arginine methylation by PRMT1, which is recruited by BMPR2, initiates BMP-Induced signaling and induces dissociation from the BMPR1B receptor at the cell surface leading to derepress downstream Smad1/Smad5 signaling.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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