Mouse Monoclonal Smad6 antibody [5H3] (STJ98387)

$379.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Mouse Monoclonal Smad6 antibody [5H3] (STJ98387)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Smad6 Monoclonal Antibody.

Alternative names:

Check alternative names for the antibody

Expand

SMAD6 antibody, MADH6 antibody,|hSMAD6 antibody|MAD homolog 6 antibody|MADH6 antibody|MADH7 antibody|Mothers against decapentaplegic homolog 6 antibody|Mothers against DPP homolog 6 antibody|SMAD 6 antibody|SMAD family member 6 antibody|SMAD mothers against DPP homolog 6 antibody|Smad6 antibody|SMAD6_HUMAN antibody|Anti-SMAD6 antibody (ab13727)
SCBT cat No: To be updated

 

Name

Smad6 Monoclonal Antibody

Catalogue No.

STJ98387

Reactivity

Human

Specificity

Smad6 Monoclonal Antibody detects endogenous levels of Smad6 protein.

Immunogen

Purified recombinant fragment of human Smad6 expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

Smad6 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

Smad6 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Mothers against decapentaplegic homolog 6 antibody, MAD homolog 6 antibody, Mothers against DPP homolog 6 antibody, SMAD family member 6 antibody, SMAD 6 antibody, Smad6 antibody, hSMAD6 antibody

Database links

Human UniProt/Swiss-Prot:O43541;Mouse UniPort/Swiss-Prot: O35182;Human Entrez Gene: 4091;Mouse Entrez Gene: 17130;Rat Entrez Gene: Rn.42472

Protein names

Mothers against decapentaplegic homolog 6 , MAD homolog 6 , Mothers against DPP homolog 6 , SMAD family member 6 , SMAD 6 , Smad6 , hSMAD6

Protein function

Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.

Protein tissue specificity

Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.

Involvement in disease

Aortic valve disease 2 (AOVD2) [MIM:614823]: A common defect in the aortic valve in which two rather than three leaflets are present. It is often associated with aortic valve calcification, stenosis and insufficiency. In extreme cases, the blood flow may be so restricted that the left ventricle fails to grow, resulting in hypoplastic left heart syndrome. . Note: The disease is caused by mutations affecting the gene represented in this entry. SMAD6 variants may contribute to increased risk of congenital cardiovascular malformations (CVM). CVM is a major cause of mortality and morbidity in childhood. In most sporadic cases that cannot be attributed to particular malformation syndromes or teratogenic exposures, there remains a substantial excess familial risk, indicating a significant genetic contribution to disease susceptibility (PubMed:22275001). .

Protein sequence and domain

Belongs to the dwarfin/SMAD family. / Contains 1 MH1 (MAD homology 1) domain. / Contains 1 MH2 (MAD homology 2) domain.

Protein post-translational modifications

Phosphorylated by BMP type 1 receptor kinase and by PRKX. / Ubiquitinated by WWP1 (By similarity). Monoubiquitinated at Lys-173 by the E2/E3 hybrid ubiquitin-protein ligase UBE2O, leading to reduced binding affinity for the activated BMP type I receptor ACVR1/ALK2, thereby enhancing BMP7 and regulating adipocyte differentiation. / Arginine methylation by PRMT1, which is recruited by BMPR2, initiates BMP-Induced signaling and induces dissociation from the BMPR1B receptor at the cell surface leading to derepress downstream Smad1/Smad5 signaling.

Protein cellular localization

Nucleus

Research area

All research areas>Transcription Regulators>Smad
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize Smad6 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!