Mouse Monoclonal SMC1 antibody [5B6] (STJ98388)

$379.00

Reactivity: Human
Applications: WB, IHC, IF, FC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal SMC1 antibody [5B6] (STJ98388)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF, FC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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SMC1A antibody, DXS423E antibody, KIAA0178 antibody, SB1.8 antibody, SMC1 antibody, SMC1L1 antibody,|CDLS2 antibody|DKFZp686L19178 antibody|DXhXs423e antibody|DXS423E antibody|KIAA0178 antibody|MGC138332 antibody|OTTHUMP00000061876 antibody|RP6 29D12.1 antibody|SB1.8 antibody|Segregation of mitotic chromosomes 1 antibody|Segregation of mitotic chromosomes like 1 antibody|SMC 1 antibody|SMC protein 1B antibody|SMC-1-beta antibody|SMC-1B antibody|SMC1 antibody|SMC1A antibody|SMC1alpha antibody|SMC1alpha protein antibody|SMC1B antibody|SMC1B_HUMAN antibody|SMC1BETA antibody|SMC1beta protein antibody|SMC1L1 antibody|SMC1L2 antibody|SMCB antibody|Structural maintenance of chromosome 1 like 1 protein antibody|Structural maintenance of chromosome 1 like 2 protein antibody|Structural maintenance of chromosomes 1A antibody|Structural maintenance of chromosomes 1B antibody|Structural maintenance of chromosomes protein 1B antibody|Anti-SMC1 antibody (ab21583)
SCBT cat No: sc-71790|sc-56746|sc-71789|sc-243890|sc-135783|sc-135784|sc-166972|sc-98691|sc-100462|sc-166115|sc-166529|

 

Name

SMC1 Monoclonal Antibody

Catalogue No.

STJ98388

Reactivity

Human

Specificity

SMC1 Monoclonal Antibody detects endogenous levels of SMC1 protein.

Immunogen

Purified recombinant fragment of human SMC1 expressed in E Coli

Host

Mouse

Applications

WB, IHC, IF, FC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

SMC1 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

SMC1 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Structural maintenance of chromosomes protein 1A antibody, SMC protein 1A antibody, SMC-1-alpha antibody, SMC-1A antibody, Sb1.8 antibody

Database links

Human UniProt/Swiss-Prot:Q14683;Mouse UniPort/Swiss-Prot: Q9CU62;Rat UniProt/Swiss-Port: Q9Z1M9;Human Entrez Gene: 8243;Mouse Entrez Gene: 24061;Rat Entrez Gene: Rn.11763

Protein names

Structural maintenance of chromosomes protein 1A , SMC protein 1A , SMC-1-alpha , SMC-1A , Sb1.8

Protein function

Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.

Involvement in disease

Cornelia de Lange syndrome 2 (CDLS2) [MIM:300590]: A form of Cornelia de Lange syndrome, a clinically heterogeneous developmental disorder associated with malformations affecting multiple systems. Characterized by facial dysmorphisms, abnormal hands and feet, growth delay, cognitive retardation, hirsutism, gastroesophageal dysfunction and cardiac, ophthalmologic and genitourinary anomalies. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC3, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable RAD21 protein, forming a ring structure (By similarity). / Belongs to the SMC family. SMC1 subfamily.

Protein post-translational modifications

Phosphorylated by ATM upon ionizing radiation in a NBS1-dependent manner. Phosphorylated by ATR upon DNA methylation in a MSH2/MSH6-dependent manner. Phosphorylation of Ser-957 and Ser-966 activates it and is required for S-phase checkpoint activation.

Protein cellular localization

Nucleus / Chromosome / Chromosome > centromere > kinetochore

Research area

All research areas>Transcription Regulators>SMC
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize SMC1 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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