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Mouse Monoclonal SOCS-3 antibody (STJ98554)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC
Recommended dilution: WB 1:1000-1:2000; IHC 1:500-1:1000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
SOCS3 antibody, CIS3 antibody, SSI3 antibody,|ATOD4 antibody|CIS 3 antibody|CIS-3 antibody|CIS3 antibody|Cish3 antibody|Cytokine induced SH2 protein 3 antibody|Cytokine-inducible SH2 protein 3 antibody|E2a Pbx1 target gene in fibroblasts 10 antibody|EF 10 antibody|MGC71791 antibody|SOCS 3 antibody|SOCS-3 antibody|Socs3 antibody|SOCS3_HUMAN antibody|SSI 3 antibody|SSI-3 antibody|SSI3 antibody|STAT induced STAT inhibitor 3 antibody|STAT-induced STAT inhibitor 3 antibody|Suppressor of cytokine signaling 3 antibody|Anti-SOCS3 antibody (ab16030)
SCBT cat No: To be updated
SOCS-3 Monoclonal Antibody
|Catalogue No.|| |
SOCS-3 Monoclonal Antibody detects endogenous levels of SOCS-3 protein.
Purified recombinant human SOCS-3 (N-terminus) protein fragments expressed in Ecoli
|Recommended dilution|| |
WB 1:1000-1:2000; IHC 1:500-1:1000
SOCS-3 Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
SOCS-3 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Suppressor of cytokine signaling 3 antibody, SOCS-3 antibody, Cytokine-inducible SH2 protein 3 antibody, CIS-3 antibody, STAT-induced STAT inhibitor 3 antibody, SSI-3 antibody
|Protein names|| |
Suppressor of cytokine signaling 3 , SOCS-3 , Cytokine-inducible SH2 protein 3 , CIS-3 , STAT-induced STAT inhibitor 3 , SSI-3
|Protein function|| |
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity). /
|Protein tissue specificity|| |
Widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. Lower levels in thymus.
|Involvement in disease|| |
Note: There is some evidence that SOCS3 may be a susceptibility gene for atopic dermatitis linked to 17q25. SOCS3 messenger RNA is significantly more highly expressed in skin from patients with atopic dermatitis than in skin from healthy controls. Furthermore, a genetic association between atopic dermatitis and a haplotype in the SOCS3 gene has been found in two independent groups of patients. .
|Protein sequence and domain|| |
The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition. / The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. / Contains 1 SH2 domain. / Contains 1 SOCS box domain.
|Protein post-translational modifications|| |
Phosphorylated on tyrosine residues after stimulation by the cytokines, IL-2, EPO or IGF1.
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St John’s Laboratory Ltd.
|Product type|| |
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