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Mouse Monoclonal SorLA antibody [7D7B11] (STJ98394)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
SORL1 antibody, C11orf32 antibody,|C11orf32 antibody||Anti-SorLA antibody (ab16642)
SCBT cat No: To be updated
SorLA Monoclonal Antibody
|Catalogue No.|| |
SorLA Monoclonal Antibody detects endogenous levels of SorLA protein.
Purified recombinant fragment of SorLA (aa2159-2214) expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
SorLA Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
SorLA Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Sortilin-related receptor antibody, Low-density lipoprotein receptor relative with 11 ligand-binding repeats antibody, LDLR relative with 11 ligand-binding repeats antibody, LR11 antibody, SorLA-1 antibody, Sorting protein-related receptor containing LDLR class A repeats antibody, SorLA antibody
|Protein names|| |
Sortilin-related receptor , Low-density lipoprotein receptor relative with 11 ligand-binding repeats , LDLR relative with 11 ligand-binding repeats , LR11 , SorLA-1 , Sorting protein-related receptor containing LDLR class A repeats , SorLA
|Protein function|| |
Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. Involved in APP trafficking to and from the Golgi apparatus. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide formation. Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization.
|Protein tissue specificity|| |
Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. Expression is significantly reduced in the frontal cortex of patients suffering from Alzheimer disease. According to PubMed:9157966, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to PubMed:8940146, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals.
|Involvement in disease|| |
Alzheimer disease (AD) [MIM:104300]: Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death. . Note: The gene represented in this entry is involved in disease pathogenesis.
|Protein sequence and domain|| |
Belongs to the VPS10-related sortilin family. SORL1 subfamily. / Contains 5 BNR repeats. / Contains 1 EGF-like domain. / Contains 6 fibronectin type-III domains. / Contains 11 LDL-receptor class A domains. / Contains 5 LDL-receptor class B repeats.
|Protein post-translational modifications|| |
The propeptide removed in the N-terminus may be cleaved by furin or homologous proteases.
|Protein cellular localization|| |
Membrane / Golgi apparatus / Endosome / Secreted
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St John’s Laboratory Ltd.
|Product type|| |
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