Mouse Monoclonal SOX-2 antibody (STJ98555)

$379.00

Reactivity: Human, Mouse, Rat, Cow, Pig, Sheep
Applications: WB
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal SOX-2 antibody (STJ98555)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB

Recommended dilution: WB 1:1000-1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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SOX2 antibody,|ANOP3 antibody|SRY-box 2 antibody|Transcription factor SOX 2 antibody|Transcription factor SOX-2 antibody|ysb antibody|Anti-SOX2 antibody (ab97959)
SCBT cat No: To be updated

 

Name

SOX-2 Monoclonal Antibody

Catalogue No.

STJ98555

Reactivity

Human, Mouse, Rat, Cow, Pig, Sheep

Specificity

SOX-2 Monoclonal Antibody detects endogenous levels of SOX-2 protein.

Immunogen

Purified recombinant human SOX-2 protein fragments expressed in Ecoli

Host

Mouse

Applications

WB

Recommended dilution

WB 1:1000-1:2000

Clonality

Monoclonal

Conjugation

Unconjugated

Formulation

SOX-2 Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Concentration

1 mg/ml

Purification

SOX-2 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Transcription factor SOX-2 antibody

Database links

Human UniProt/Swiss-Prot:P48431;Mouse UniPort/Swiss-Prot: P48432;Rat UniProt/Swiss-Port: D4A543;Human Entrez Gene: 6657;Mouse Entrez Gene: 20674;Rat Entrez Gene: Rn.17369

Protein names

Transcription factor SOX-2

Protein function

Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).

Involvement in disease

Microphthalmia, syndromic, 3 (MCOPS3) [MIM:206900]: A disease characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Contains 1 HMG box DNA-binding domain.

Protein post-translational modifications

Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.

Protein cellular localization

Nucleus

Research area

All research areas>Transcription Regulators>Sox-2
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize SOX-2 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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