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Mouse Monoclonal SOX-2 antibody (STJ98555)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB
Recommended dilution: WB 1:1000-1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for SOX-2 Monoclonal Antibody.
Check alternative names for the antibodyExpand
SOX2 antibody,|ANOP3 antibody|SRY-box 2 antibody|Transcription factor SOX 2 antibody|Transcription factor SOX-2 antibody|ysb antibody|Anti-SOX2 antibody (ab97959)
SCBT cat No: To be updated
SOX-2 Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat, Cow, Pig, Sheep
SOX-2 Monoclonal Antibody detects endogenous levels of SOX-2 protein.
Purified recombinant human SOX-2 protein fragments expressed in Ecoli
|Recommended dilution|| |
SOX-2 Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
SOX-2 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Transcription factor SOX-2 antibody
|Protein names|| |
Transcription factor SOX-2
|Protein function|| |
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
|Involvement in disease|| |
Microphthalmia, syndromic, 3 (MCOPS3) [MIM:206900]: A disease characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Contains 1 HMG box DNA-binding domain.
|Protein post-translational modifications|| |
Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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