Mouse Monoclonal Stat3 antibody [3B5] (STJ98400)

$379.00

Reactivity: Human, Mouse, Monkey
Applications: WB, IHC, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Stat3 antibody [3B5] (STJ98400)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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STAT3 antibody, APRF antibody,|1110034C02Rik antibody|Acute Phase Response Factor antibody|Acute-phase response factor antibody|ADMIO antibody|APRF antibody|AW109958 antibody|DNA binding protein APRF antibody|FLJ20882 antibody|HIES antibody|MGC16063 antibody|Signal transducer and activator of transcription 3 (acute phase response factor) antibody|Signal transducer and activator of transcription 3 antibody|STAT 3 antibody|Stat3 antibody|STAT3_HUMAN antibody|Anti-STAT3 antibody [EPR787Y] (ab68153)
SCBT cat No: sc-56747|sc-71792|sc-81523|sc-8059|sc-293059|sc-136193|sc-135649|sc-21876|sc-8001|sc-7993|sc-28296|sc-136194|sc-16317|sc-22160|sc-101804|

 

Name

Stat3 Monoclonal Antibody

Catalogue No.

STJ98400

Reactivity

Human, Mouse, Monkey

Specificity

Stat3 Monoclonal Antibody detects endogenous levels of Stat3 protein.

Immunogen

Purified recombinant fragment of human Stat3 expressed in E Coli

Host

Mouse

Applications

WB, IHC, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

Stat3 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

Stat3 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Signal transducer and activator of transcription 3 antibody, Acute-phase response factor antibody

Database links

Human UniProt/Swiss-Prot:P40763;Mouse UniPort/Swiss-Prot: P42227;Rat UniProt/Swiss-Port: P52631;Human Entrez Gene: 6774;Mouse Entrez Gene: 20848;Rat Entrez Gene: Rn.10247

Protein names

Signal transducer and activator of transcription 3 , Acute-phase response factor

Protein function

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene . May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 . Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation . Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity.

Protein tissue specificity

Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Involvement in disease

Hyperimmunoglobulin E recurrent infection syndrome, autosomal dominant (AD-HIES) [MIM:147060]: A rare disorder of immunity and connective tissue characterized by immunodeficiency, chronic eczema, recurrent Staphylococcal infections, increased serum IgE, eosinophilia, distinctive coarse facial appearance, abnormal dentition, hyperextensibility of the joints, and bone fractures. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Autoimmune disease, multisystem, infantile-onset, 1 (ADMIO1) [MIM:615952]: A disorder characterized by early childhood onset of a spectrum of autoimmune manifestations affecting multiple organs, including insulin-dependent diabetes mellitus and autoimmune enteropathy or celiac disease. Other features include short stature, non-specific dermatitis, hypothyroidism, autoimmune arthritis, and delayed puberty. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the transcription factor STAT family. / Contains 1 SH2 domain.

Protein post-translational modifications

Tyrosine phosphorylated upon stimulation with EGF. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Activated through tyrosine phosphorylation by BMX. Tyrosine phosphorylated in response to IL6, IL11, LIF, CNTF, KITLG/SCF, CSF1, EGF, PDGF, IFN-alpha, LEP and OSM. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity. ARL2BP may participate in keeping the phosphorylated state of STAT3 within the nucleus. Upon LPS challenge, phosphorylated within the nucleus by IRAK1. Upon erythropoietin treatment, phosphorylated on Ser-727 by RPS6KA5. Phosphorylation at Tyr-705 by PTK6 or FER leads to an increase of its transcriptional activity. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates IL6/interleukin-6 signaling.

Protein cellular localization

Cytoplasm / Nucleus

Research area

All research areas>Transcription Regulators>Stat3
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize Stat3 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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