Mouse Monoclonal Stat5b antibody [5B3] (STJ98401)

$379.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Stat5b antibody [5B3] (STJ98401)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Stat5b Monoclonal Antibody.

Alternative names:

Check alternative names for the antibody

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STAT5B antibody,|Signal transducer and activator of transcription 5B antibody|STA5B_HUMAN antibody|STAT5 antibody|Stat5b antibody|Transcription factor STAT5B antibody|Anti-STAT5b [EPR16671] antibody (ab178941)
SCBT cat No: sc-81524|sc-12893|sc-101806|sc-81525|sc-136019|sc-101808|sc-11762|

 

Name

Stat5b Monoclonal Antibody

Catalogue No.

STJ98401

Reactivity

Human

Specificity

Stat5b Monoclonal Antibody detects endogenous levels of Stat5b protein.

Immunogen

Purified recombinant fragment of human Stat5b expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

Stat5b Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

Stat5b Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Signal transducer and activator of transcription 5B antibody

Database links

Human UniProt/Swiss-Prot:P51692;Mouse UniPort/Swiss-Prot: P42232;Rat UniProt/Swiss-Port: P52632;Human Entrez Gene: 6777;Mouse Entrez Gene: 20851;Rat Entrez Gene: Rn.54486

Protein names

Signal transducer and activator of transcription 5B

Protein function

Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription.

Involvement in disease

Growth hormone insensitivity with immunodeficiency (GHII) [MIM:245590]: A disease characterized by short stature, growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, resistance to hexogeneous growth hormone therapy, and recurrent infections. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the transcription factor STAT family. / Contains 1 SH2 domain.

Protein post-translational modifications

Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2. Phosphorylation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates prolactin signaling pathway.

Protein cellular localization

Cytoplasm / Nucleus

Research area

All research areas>Transcription Regulators>Stat5
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize Stat5b Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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