Mouse Monoclonal SUZ12 antibody [2C11] (STJ98404)

$379.00

Reactivity: Human
Applications: WB, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal SUZ12 antibody [2C11] (STJ98404)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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SUZ12 antibody, CHET9 antibody, JJAZ1 antibody, KIAA0160 antibody,|ChET 9 protein antibody|CHET9 antibody|Chromatin precipitated E2F target 9 protein antibody|JJAZ1 antibody|Joined to JAZF1 protein antibody|KIAA0160 antibody|Polycomb protein SUZ12 antibody|Suppressor of zeste 12 homolog antibody|Suppressor of zeste 12 protein homolog antibody|SUZ12 antibody|SUZ12 polycomb repressive complex 2 subunit antibody|SUZ12_HUMAN antibody|Anti-SUZ12 antibody – ChIP Grade (ab12073)
SCBT cat No: To be updated

 

Name

SUZ12 Monoclonal Antibody

Catalogue No.

STJ98404

Reactivity

Human

Specificity

SUZ12 Monoclonal Antibody detects endogenous levels of SUZ12 protein.

Immunogen

Purified recombinant fragment of human SUZ12 expressed in E Coli

Host

Mouse

Applications

WB, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

SUZ12 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

SUZ12 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Polycomb protein SUZ12 antibody, Chromatin precipitated E2F target 9 protein antibody, ChET 9 protein antibody, Joined to JAZF1 protein antibody, Suppressor of zeste 12 protein homolog antibody

Database links

Human UniProt/Swiss-Prot:Q15022;Mouse UniPort/Swiss-Prot: Q80U70;Human Entrez Gene: 23512;Mouse Entrez Gene: 52615;

Protein names

Polycomb protein SUZ12 , Chromatin precipitated E2F target 9 protein , ChET 9 protein , Joined to JAZF1 protein , Suppressor of zeste 12 protein homolog

Protein function

Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates ‘Lys-9’ (H3K9me) and ‘Lys-27’ (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.

Protein tissue specificity

Overexpressed in breast and colon cancer.

Involvement in disease

Note: A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors. Translocation t(7;17)(p15;q21) with JAZF1. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer. .

Protein sequence and domain

Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family. / Contains 1 C2H2-type zinc finger.

Protein post-translational modifications

Sumoylated, probably by PIAS2.

Protein cellular localization

Nucleus

Research area

All research areas>Transcription Regulators>SUZ12
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize SUZ12 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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