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Mouse Monoclonal SUZ12 antibody [3D10] (STJ98405)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
SUZ12 antibody, CHET9 antibody, JJAZ1 antibody, KIAA0160 antibody,|ChET 9 protein antibody|CHET9 antibody|Chromatin precipitated E2F target 9 protein antibody|JJAZ1 antibody|Joined to JAZF1 protein antibody|KIAA0160 antibody|Polycomb protein SUZ12 antibody|Suppressor of zeste 12 homolog antibody|Suppressor of zeste 12 protein homolog antibody|SUZ12 antibody|SUZ12 polycomb repressive complex 2 subunit antibody|SUZ12_HUMAN antibody|Anti-SUZ12 antibody – ChIP Grade (ab12073)
SCBT cat No: To be updated
SUZ12 Monoclonal Antibody
|Catalogue No.|| |
SUZ12 Monoclonal Antibody detects endogenous levels of SUZ12 protein.
Purified recombinant fragment of human SUZ12 expressed in E Coli
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
SUZ12 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
SUZ12 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Polycomb protein SUZ12 antibody, Chromatin precipitated E2F target 9 protein antibody, ChET 9 protein antibody, Joined to JAZF1 protein antibody, Suppressor of zeste 12 protein homolog antibody
|Protein names|| |
Polycomb protein SUZ12 , Chromatin precipitated E2F target 9 protein , ChET 9 protein , Joined to JAZF1 protein , Suppressor of zeste 12 protein homolog
|Protein function|| |
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates ‘Lys-9’ (H3K9me) and ‘Lys-27’ (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
|Protein tissue specificity|| |
Overexpressed in breast and colon cancer.
|Involvement in disease|| |
Note: A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors. Translocation t(7;17)(p15;q21) with JAZF1. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer. .
|Protein sequence and domain|| |
Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family. / Contains 1 C2H2-type zinc finger.
|Protein post-translational modifications|| |
Sumoylated, probably by PIAS2.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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