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Mouse Monoclonal Synaptotagmin 1 antibody [8G11B10] (STJ98407)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for Synaptotagmin 1 Monoclonal Antibody.
Check alternative names for the antibodyExpand
SYT1 antibody, SVP65 antibody, SYT antibody,|DKFZp781D2042 antibody|FLJ42519 antibody|P65 antibody|SVP65 antibody|synaptotagmin 1 antibody|synaptotagmin 2 antibody|Synaptotagmin I antibody|Synaptotagmin II antibody|SYT antibody|SYT1 antibody|SYT2 antibody|SytI antibody|SytII antibody|Anti-Synaptotagmin 1 antibody (ab133856)
SCBT cat No: To be updated
Synaptotagmin 1 Monoclonal Antibody
|Catalogue No.|| |
Synaptotagmin 1 Monoclonal Antibody detects endogenous levels of Synaptotagmin 1 protein.
Purified recombinant fragment of Synaptotagmin 1 expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
Synaptotagmin 1 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
Synaptotagmin 1 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Synaptotagmin-1 antibody, Synaptotagmin I antibody, SytI antibody, p65 antibody
|Protein names|| |
Synaptotagmin-1 , Synaptotagmin I , SytI , p65
|Protein function|| |
May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca2+-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca2+-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes . / Ca2+
|Protein tissue specificity|| |
Expressed in melanocytes (PubMed:23999003).
|Involvement in disease|| |
Note: A SYT1 rare mutation has been found in a child with a severe neuro-developmental disorder. The individual harboring this variant shows early onset dyskinetic movement disorder, severe motor delay and profound cognitive impairment, suggesting that SYT1 may play a role in the pathogenesis of this neuro-developmental disorder. .
|Protein sequence and domain|| |
The first C2 domain mediates Ca2+-dependent phospholipid binding. / The second C2 domain mediates interaction with SV2A and probably with STN2. / Belongs to the synaptotagmin family. / Contains 2 C2 domains.
|Protein cellular localization|| |
Cytoplasmic vesicle > secretory vesicle membrane / Single-pass membrane protein / Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane / Single-pass membrane protein / Cytoplasmic vesicle > secretory vesicle > chromaffin granule membrane / Single-pass membrane protein / Cytoplasm
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St John’s Laboratory Ltd.
|Product type|| |
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