Mouse Monoclonal Synaptotagmin 1 antibody [8G11B10] (STJ98407)

$379.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Synaptotagmin 1 antibody [8G11B10] (STJ98407)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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SYT1 antibody, SVP65 antibody, SYT antibody,|DKFZp781D2042 antibody|FLJ42519 antibody|P65 antibody|SVP65 antibody|synaptotagmin 1 antibody|synaptotagmin 2 antibody|Synaptotagmin I antibody|Synaptotagmin II antibody|SYT antibody|SYT1 antibody|SYT2 antibody|SytI antibody|SytII antibody|Anti-Synaptotagmin 1 antibody (ab133856)
SCBT cat No: To be updated

 

Name

Synaptotagmin 1 Monoclonal Antibody

Catalogue No.

STJ98407

Reactivity

Human

Specificity

Synaptotagmin 1 Monoclonal Antibody detects endogenous levels of Synaptotagmin 1 protein.

Immunogen

Purified recombinant fragment of Synaptotagmin 1 expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

Synaptotagmin 1 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

Synaptotagmin 1 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Synaptotagmin-1 antibody, Synaptotagmin I antibody, SytI antibody, p65 antibody

Database links

Human UniProt/Swiss-Prot:P21579;Mouse UniPort/Swiss-Prot: P46096;Rat UniProt/Swiss-Port: P21707;Human Entrez Gene: 6857;Mouse Entrez Gene: 20979;Rat Entrez Gene: Rn.216272

Protein names

Synaptotagmin-1 , Synaptotagmin I , SytI , p65

Protein function

May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca2+-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca2+-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes . / Ca2+

Protein tissue specificity

Expressed in melanocytes (PubMed:23999003).

Involvement in disease

Note: A SYT1 rare mutation has been found in a child with a severe neuro-developmental disorder. The individual harboring this variant shows early onset dyskinetic movement disorder, severe motor delay and profound cognitive impairment, suggesting that SYT1 may play a role in the pathogenesis of this neuro-developmental disorder. .

Protein sequence and domain

The first C2 domain mediates Ca2+-dependent phospholipid binding. / The second C2 domain mediates interaction with SV2A and probably with STN2. / Belongs to the synaptotagmin family. / Contains 2 C2 domains.

Protein cellular localization

Cytoplasmic vesicle > secretory vesicle membrane / Single-pass membrane protein / Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane / Single-pass membrane protein / Cytoplasmic vesicle > secretory vesicle > chromaffin granule membrane / Single-pass membrane protein / Cytoplasm

Research area

All research areas>Neurobiology>APBA2BP
(View all antibody categories related to Neurobiology)

Note

AntibodyPlus can customize Synaptotagmin 1 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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