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Mouse Monoclonal Syntenin-1 antibody (STJ98556)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB
Recommended dilution: WB 1:1000-1:2000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
SDCBP antibody, MDA9 antibody, SYCL antibody,|MDA-9 antibody|MDA9 antibody|Melanoma differentiation-associated protein 9 antibody|Pro-TGF-alpha cytoplasmic domain-interacting protein 18 antibody|Scaffold protein Pbp1 antibody|SDCB1_HUMAN antibody|SDCBP antibody|ST1 antibody|SYCL antibody|Syndecan binding protein (syntenin) antibody|Syndecan binding protein 1 antibody|Syndecan-binding protein 1 antibody|Syntenin 1 antibody|Syntenin-1 antibody|TACIP18 antibody|Anti-Syntenin antibody [EPR8102] (ab133267)
SCBT cat No: To be updated
Syntenin-1 Monoclonal Antibody
|Catalogue No.|| |
Human, Rat, Dog, Pig
Syntenin-1 Monoclonal Antibody detects endogenous levels of Syntenin-1 protein.
Purified recombinant human Syntenin-1 protein fragments expressed in Ecoli
|Recommended dilution|| |
Syntenin-1 Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
Syntenin-1 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Syntenin-1 antibody, Melanoma differentiation-associated protein 9 antibody, MDA-9 antibody, Pro-TGF-alpha cytoplasmic domain-interacting protein 18 antibody, TACIP18 antibody, Scaffold protein Pbp1 antibody, Syndecan-binding protein 1 antibody
|Protein names|| |
Syntenin-1 , Melanoma differentiation-associated protein 9 , MDA-9 , Pro-TGF-alpha cytoplasmic domain-interacting protein 18 , TACIP18 , Scaffold protein Pbp1 , Syndecan-binding protein 1
|Protein function|| |
Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis . Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 . In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis . Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types . In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) . May also play a role in vesicular trafficking . Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway .
|Protein tissue specificity|| |
Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma (at protein level) (PubMed:25893292). Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta.
|Protein sequence and domain|| |
Contains 2 PDZ (DHR) domains.
|Protein post-translational modifications|| |
Phosphorylated on tyrosine residues.
|Protein cellular localization|| |
Cell junction > focal adhesion / Cell junction > adherens junction / Cell membrane / Peripheral membrane protein / Endoplasmic reticulum membrane / Peripheral membrane protein / Nucleus / Melanosome / Cytoplasm > cytosol / Cytoplasm > cytoskeleton / Secreted > exosome / Membrane raft
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St John’s Laboratory Ltd.
|Product type|| |
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