Mouse Monoclonal Syntenin-1 antibody (STJ98556)

$379.00

Reactivity: Human, Rat, Dog, Pig
Applications: WB
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Syntenin-1 antibody (STJ98556)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB

Recommended dilution: WB 1:1000-1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

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SDCBP antibody, MDA9 antibody, SYCL antibody,|MDA-9 antibody|MDA9 antibody|Melanoma differentiation-associated protein 9 antibody|Pro-TGF-alpha cytoplasmic domain-interacting protein 18 antibody|Scaffold protein Pbp1 antibody|SDCB1_HUMAN antibody|SDCBP antibody|ST1 antibody|SYCL antibody|Syndecan binding protein (syntenin) antibody|Syndecan binding protein 1 antibody|Syndecan-binding protein 1 antibody|Syntenin 1 antibody|Syntenin-1 antibody|TACIP18 antibody|Anti-Syntenin antibody [EPR8102] (ab133267)
SCBT cat No: To be updated

 

Name

Syntenin-1 Monoclonal Antibody

Catalogue No.

STJ98556

Reactivity

Human, Rat, Dog, Pig

Specificity

Syntenin-1 Monoclonal Antibody detects endogenous levels of Syntenin-1 protein.

Immunogen

Purified recombinant human Syntenin-1 protein fragments expressed in Ecoli

Host

Mouse

Applications

WB

Recommended dilution

WB 1:1000-1:2000

Clonality

Monoclonal

Conjugation

Unconjugated

Formulation

Syntenin-1 Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Concentration

1 mg/ml

Purification

Syntenin-1 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Syntenin-1 antibody, Melanoma differentiation-associated protein 9 antibody, MDA-9 antibody, Pro-TGF-alpha cytoplasmic domain-interacting protein 18 antibody, TACIP18 antibody, Scaffold protein Pbp1 antibody, Syndecan-binding protein 1 antibody

Database links

Human UniProt/Swiss-Prot:O00560;Mouse UniPort/Swiss-Prot: O08992;Rat UniProt/Swiss-Port: Q9JI92;Human Entrez Gene: 6386;Mouse Entrez Gene: 53378;Rat Entrez Gene: Rn.4309

Protein names

Syntenin-1 , Melanoma differentiation-associated protein 9 , MDA-9 , Pro-TGF-alpha cytoplasmic domain-interacting protein 18 , TACIP18 , Scaffold protein Pbp1 , Syndecan-binding protein 1

Protein function

Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis . Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 . In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis . Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types . In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) . May also play a role in vesicular trafficking . Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway .

Protein tissue specificity

Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma (at protein level) (PubMed:25893292). Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta.

Protein sequence and domain

Contains 2 PDZ (DHR) domains.

Protein post-translational modifications

Phosphorylated on tyrosine residues.

Protein cellular localization

Cell junction > focal adhesion / Cell junction > adherens junction / Cell membrane / Peripheral membrane protein / Endoplasmic reticulum membrane / Peripheral membrane protein / Nucleus / Melanosome / Cytoplasm > cytosol / Cytoplasm > cytoskeleton / Secreted > exosome / Membrane raft

Research area

All research areas>Neurobiology>syntenin
(View all antibody categories related to Neurobiology)

Note

AntibodyPlus can customize Syntenin-1 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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