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Mouse Monoclonal TAB2 antibody [3B5] (STJ98411)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, FC, ELISA
Recommended dilution: WB 1:500-1:2000; FC 1:200-1:400; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
TAB2 antibody, KIAA0733 antibody, MAP3K7IP2 antibody,|CHTD2 antibody|FLJ21885 antibody|KIAA0733 antibody|MAP3K7IP2 antibody|Mitogen activated protein kinase kinase kinase 7 interacting protein 2 antibody|Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 antibody|OTTHUMP00000040125 antibody|TAB 2 antibody|TAB-2 antibody|Tab2 antibody|TAB2_HUMAN antibody|TAK1 binding protein 2 antibody|TAK1-binding protein 2 antibody|TGF beta activated kinase 1/MAP3K7 binding protein 2 antibody|TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 antibody|TGF-beta-activated kinase 1-binding protein 2 antibody|Anti-TAB2 antibody (ab172412)
SCBT cat No: To be updated
TAB2 Monoclonal Antibody
|Catalogue No.|| |
TAB2 Monoclonal Antibody detects endogenous levels of TAB2 protein.
Purified recombinant fragment of human TAB2 expressed in E Coli
WB, FC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; FC 1:200-1:400; ELISA 1:10000
TAB2 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
TAB2 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 antibody, Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 antibody, TAK1-binding protein 2 antibody, TAB-2 antibody, TGF-beta-activated kinase 1-binding protein 2 antibody
|Protein names|| |
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 , Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 , TAK1-binding protein 2 , TAB-2 , TGF-beta-activated kinase 1-binding protein 2
|Protein function|| |
Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of ‘Lys-63’-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at ‘Thr-187’. Involved in heart development.
|Protein tissue specificity|| |
Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves.
|Involvement in disease|| |
Congenital heart defects, multiple types, 2 (CHTD2) [MIM:614980]: A disease characterized by congenital developmental abnormalities involving structures of the heart. CHTD2 patients have left ventricular outflow tract obstruction, subaortic stenosis, residual aortic regurgitation, atrial fibrillation, bicuspid aortic valve and aortic dilation. . Note: The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving TAB2 has been found in a family with congenital heart disease. Translocation t(2;6)(q21;q25).
|Protein sequence and domain|| |
The RanBP2-type zinc finger (NZF) mediates binding to two consecutive ‘Lys-63’-linked ubiquitins. / Contains 1 CUE domain. / Contains 1 RanBP2-type zinc finger.
|Protein post-translational modifications|| |
Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Ubiquitination involves RBCK1 leading to proteasomal degradation. / Phosphorylated.
|Protein cellular localization|| |
Membrane / Peripheral membrane protein / Cytoplasm > cytosol
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St John’s Laboratory Ltd.
|Product type|| |
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