Mouse Monoclonal TAB2 antibody [3B5] (STJ98411)

$379.00

Reactivity: Human
Applications: WB, FC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal TAB2 antibody [3B5] (STJ98411)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, FC, ELISA

Recommended dilution: WB 1:500-1:2000; FC 1:200-1:400; ELISA 1:10000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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TAB2 antibody, KIAA0733 antibody, MAP3K7IP2 antibody,|CHTD2 antibody|FLJ21885 antibody|KIAA0733 antibody|MAP3K7IP2 antibody|Mitogen activated protein kinase kinase kinase 7 interacting protein 2 antibody|Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 antibody|OTTHUMP00000040125 antibody|TAB 2 antibody|TAB-2 antibody|Tab2 antibody|TAB2_HUMAN antibody|TAK1 binding protein 2 antibody|TAK1-binding protein 2 antibody|TGF beta activated kinase 1/MAP3K7 binding protein 2 antibody|TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 antibody|TGF-beta-activated kinase 1-binding protein 2 antibody|Anti-TAB2 antibody (ab172412)
SCBT cat No: To be updated

 

Name

TAB2 Monoclonal Antibody

Catalogue No.

STJ98411

Reactivity

Human

Specificity

TAB2 Monoclonal Antibody detects endogenous levels of TAB2 protein.

Immunogen

Purified recombinant fragment of human TAB2 expressed in E Coli

Host

Mouse

Applications

WB, FC, ELISA

Recommended dilution

WB 1:500-1:2000; FC 1:200-1:400; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

TAB2 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

TAB2 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 antibody, Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 antibody, TAK1-binding protein 2 antibody, TAB-2 antibody, TGF-beta-activated kinase 1-binding protein 2 antibody

Database links

Human UniProt/Swiss-Prot:Q9NYJ8;Mouse UniPort/Swiss-Prot: Q99K90;Rat UniProt/Swiss-Port: Q5U303;Human Entrez Gene: 23118;Mouse Entrez Gene: 68652;Rat Entrez Gene: Rn.231700

Protein names

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 , Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 , TAK1-binding protein 2 , TAB-2 , TGF-beta-activated kinase 1-binding protein 2

Protein function

Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of ‘Lys-63’-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at ‘Thr-187’. Involved in heart development.

Protein tissue specificity

Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves.

Involvement in disease

Congenital heart defects, multiple types, 2 (CHTD2) [MIM:614980]: A disease characterized by congenital developmental abnormalities involving structures of the heart. CHTD2 patients have left ventricular outflow tract obstruction, subaortic stenosis, residual aortic regurgitation, atrial fibrillation, bicuspid aortic valve and aortic dilation. . Note: The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving TAB2 has been found in a family with congenital heart disease. Translocation t(2;6)(q21;q25).

Protein sequence and domain

The RanBP2-type zinc finger (NZF) mediates binding to two consecutive ‘Lys-63’-linked ubiquitins. / Contains 1 CUE domain. / Contains 1 RanBP2-type zinc finger.

Protein post-translational modifications

Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Ubiquitination involves RBCK1 leading to proteasomal degradation. / Phosphorylated.

Protein cellular localization

Membrane / Peripheral membrane protein / Cytoplasm > cytosol

Research area

All research areas>Signaling Intermediates>TAB2
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize TAB2 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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