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Mouse Monoclonal Tec antibody [3A5] (STJ98416)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for Tec Monoclonal Antibody.
Check alternative names for the antibodyExpand
TEC antibody, PSCTK4 antibody,|MGC126760 antibody|MGC126762 antibody|PSCTK4 antibody|Tec antibody|Tec protein tyrosine kinase antibody|TEC_HUMAN antibody|Tyrosine protein kinase antibody|Tyrosine-protein kinase Tec antibody|Anti-Tec antibody [Y398] (ab32368)
SCBT cat No: To be updated
Tec Monoclonal Antibody
|Catalogue No.|| |
Tec Monoclonal Antibody detects endogenous levels of Tec protein.
Purified recombinant fragment of Tec expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
Tec Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
Tec Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Tyrosine-protein kinase T
|Protein names|| |
Tyrosine-protein kinase T
|Protein function|| |
Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 ‘Tyr-215’. May also be involved in the regulation of osteoclast differentiation. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. / Zn2+ / Activated by tyrosine phosphorylation by a wide range of cytokine stimulations. When T-cells or B-cells receptors are activated, a series of phosphorylation leads to the recruitment of TEC to the cell membrane, where it is phosphorylated at Tyr-519. Also activated in response to SCF. Integrin engagement induces tyrosine phosphorylation of TEC in platelets. STAP1 participates in a positive feedback loop by increasing the activity of TEC. SOCS1 is an inhibitor of TEC kinase activity.
|Protein tissue specificity|| |
Expressed in a wide range of cells, including hematopoietic cell lines like myeloid, B-, and T-cell lineages.
|Protein sequence and domain|| |
The PH domain mediates the binding to inositol polyphosphate and phosphoinositides, leading to its targeting to the plasma membrane. It is extended in the BTK kinase family by a region designated the TH (Tec homology) domain, which consists of about 80 residues preceding the SH3 domain. / The SH3 domain is essential for its targeting to activated CD28 costimulatory molecule. / Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. / Contains 1 Btk-type zinc finger. / Contains 1 PH domain. / Contains 1 protein kinase domain. / Contains 1 SH2 domain. / Contains 1 SH3 domain.
|Protein post-translational modifications|| |
Following B-cell or T-cell receptors engagement, translocates to the plasma membrane where it gets phosphorylated at Tyr-519. Undergoes also tyrosine phosphorylation during platelet activation.
|Protein cellular localization|| |
Cytoplasm / Cell membrane; Peripheral membrane protein / Cytoplasm > cytoskeleton
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St John’s Laboratory Ltd.
|Product type|| |
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