Mouse Monoclonal TGFbeta1 antibody [4F9C10; 1B11B7] (STJ98418)

$379.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal TGFbeta1 antibody [4F9C10; 1B11B7] (STJ98418)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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TGFB1 antibody, TGFB antibody,|Cartilage-inducing factor antibody|CED antibody|Differentiation inhibiting factor antibody|DPD1 antibody|LAP antibody|Latency-associated peptide antibody|Prepro transforming growth factor beta 1 antibody|TGF beta 1 antibody|TGF beta antibody|TGF beta 1 protein antibody|TGF-beta 1 protein antibody|TGF-beta-1 antibody|TGF-beta-5 antibody|TGF-beta1 antibody|TGFB antibody|Tgfb-1 antibody|tgfb1 antibody|TGFB1_HUMAN antibody|TGFbeta antibody|TGFbeta1 antibody|Transforming Growth Factor b1 antibody|Transforming Growth Factor beta 1 antibody|Transforming growth factor beta 1a antibody|transforming growth factor beta-1 antibody|transforming growth factor, beta 1 antibody|Transforming Growth Factor-?1 antibody|Anti-TGF beta 1 antibody (ab92486)
SCBT cat No: sc-80151|sc-34830|sc-160486|sc-81610|sc-19784|sc-28541|sc-19783|sc-376270|sc-398601|sc-271958|sc-514618|sc-365462|

 

Name

TGFbeta1 Monoclonal Antibody

Catalogue No.

STJ98418

Reactivity

Human

Specificity

TGFbeta1 Monoclonal Antibody detects endogenous levels of TGFbeta1 protein.

Immunogen

Purified recombinant fragment of TGFbeta1 expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG2a

Formulation

TGFbeta1 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

TGFbeta1 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Transforming growth factor beta-1 antibody, TGF-beta-1 antibody

Database links

Human UniProt/Swiss-Prot:P01137;Mouse UniPort/Swiss-Prot: P04202;Rat UniProt/Swiss-Port: P17246;Human Entrez Gene: 7040;Mouse Entrez Gene: 21803;Rat Entrez Gene: Rn.40136

Protein names

Transforming growth factor beta-1 , TGF-beta-1

Protein function

Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus . Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types .

Protein tissue specificity

Highly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage.

Involvement in disease

Camurati-Engelmann disease (CAEND) [MIM:131300]: An autosomal dominant disorder characterized by hyperostosis and sclerosis of the diaphyses of long bones. The disease typically presents in early childhood with pain, muscular weakness and waddling gait, and in some cases other features such as exophthalmos, facial paralysis, hearing difficulties and loss of vision. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

The ‘straitjacket’ and ‘arm’ domains encircle the growth factor monomers and are fastened together by strong bonding between Lys-56 and Tyr-103/Tyr-104. Activation of TGF-beta1 requires the binding of integrin alpha-V to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-beta binding proteins. The sheer physical force unfastens the straitjacket and releases the active growth factor dimer (By similarity). / Belongs to the TGF-beta family.

Protein post-translational modifications

Glycosylated. / The precursor is cleaved into mature TGF-beta-1 and LAP, which remains non-covalently linked to mature TGF-beta-1 rendering it inactive.

Protein cellular localization

Secreted > extracellular space > extracellular matrix

Research area

All research areas>Growth Factors and Hormones>TGF
(View all antibody categories related to Growth Factors and Hormones)

Note

AntibodyPlus can customize TGFbeta1 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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