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Mouse Monoclonal TGFbeta1 antibody [4F9C10; 1B11B7] (STJ98418)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
TGFB1 antibody, TGFB antibody,|Cartilage-inducing factor antibody|CED antibody|Differentiation inhibiting factor antibody|DPD1 antibody|LAP antibody|Latency-associated peptide antibody|Prepro transforming growth factor beta 1 antibody|TGF beta 1 antibody|TGF beta antibody|TGF beta 1 protein antibody|TGF-beta 1 protein antibody|TGF-beta-1 antibody|TGF-beta-5 antibody|TGF-beta1 antibody|TGFB antibody|Tgfb-1 antibody|tgfb1 antibody|TGFB1_HUMAN antibody|TGFbeta antibody|TGFbeta1 antibody|Transforming Growth Factor b1 antibody|Transforming Growth Factor beta 1 antibody|Transforming growth factor beta 1a antibody|transforming growth factor beta-1 antibody|transforming growth factor, beta 1 antibody|Transforming Growth Factor-?1 antibody|Anti-TGF beta 1 antibody (ab92486)
SCBT cat No: sc-80151|sc-34830|sc-160486|sc-81610|sc-19784|sc-28541|sc-19783|sc-376270|sc-398601|sc-271958|sc-514618|sc-365462|
TGFbeta1 Monoclonal Antibody
|Catalogue No.|| |
TGFbeta1 Monoclonal Antibody detects endogenous levels of TGFbeta1 protein.
Purified recombinant fragment of TGFbeta1 expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
TGFbeta1 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
TGFbeta1 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Transforming growth factor beta-1 antibody, TGF-beta-1 antibody
|Protein names|| |
Transforming growth factor beta-1 , TGF-beta-1
|Protein function|| |
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus . Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types .
|Protein tissue specificity|| |
Highly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage.
|Involvement in disease|| |
Camurati-Engelmann disease (CAEND) [MIM:131300]: An autosomal dominant disorder characterized by hyperostosis and sclerosis of the diaphyses of long bones. The disease typically presents in early childhood with pain, muscular weakness and waddling gait, and in some cases other features such as exophthalmos, facial paralysis, hearing difficulties and loss of vision. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
The ‘straitjacket’ and ‘arm’ domains encircle the growth factor monomers and are fastened together by strong bonding between Lys-56 and Tyr-103/Tyr-104. Activation of TGF-beta1 requires the binding of integrin alpha-V to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-beta binding proteins. The sheer physical force unfastens the straitjacket and releases the active growth factor dimer (By similarity). / Belongs to the TGF-beta family.
|Protein post-translational modifications|| |
Glycosylated. / The precursor is cleaved into mature TGF-beta-1 and LAP, which remains non-covalently linked to mature TGF-beta-1 rendering it inactive.
|Protein cellular localization|| |
Secreted > extracellular space > extracellular matrix
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St John’s Laboratory Ltd.
|Product type|| |
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