Mouse Monoclonal TIF1gamma antibody (STJ98564)

$379.00

Reactivity: Human, Mouse, Rat, Cow, Dog, Pig
Applications: WB, IF
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal TIF1gamma antibody (STJ98564)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IF

Recommended dilution: WB 1:1000-1:2000; IF 1:100-1:500

Recommended protocols: check protocols

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Alternative names:

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SCBT cat No: To be updated

 

Name

TIF1gamma Monoclonal Antibody

Catalogue No.

STJ98564

Reactivity

Human, Mouse, Rat, Cow, Dog, Pig

Specificity

TIF1gamma Monoclonal Antibody detects endogenous levels of TIF1gamma protein.

Immunogen

Purified recombinant human TIF1gamma (C-terminus) protein fragments expressed in Ecoli

Host

Mouse

Applications

WB, IF

Recommended dilution

WB 1:1000-1:2000; IF 1:100-1:500

Clonality

Monoclonal

Conjugation

Unconjugated

Formulation

TIF1gamma Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Concentration

1 mg/ml

Purification

TIF1gamma Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

E3 ubiquitin-protein ligase TRIM33 antibody, Ectodermin homolog antibody, RET-fused gene 7 protein antibody, Protein Rfg7 antibody, Transcription intermediary factor 1-gamma antibody, TIF1-gamma antibody, Tripartite motif-containing protein 33 antibody

Database links

Human UniProt/Swiss-Prot:Q9UPN9;Mouse UniPort/Swiss-Prot: Q99PP7;Rat UniProt/Swiss-Port: D3ZUK4;Human Entrez Gene: 51592;Mouse Entrez Gene: 94093;Rat Entrez Gene: Rn.233105

Protein names

E3 ubiquitin-protein ligase TRIM33 , Ectodermin homolog , RET-fused gene 7 protein , Protein Rfg7 , Transcription intermediary factor 1-gamma , TIF1-gamma , Tripartite motif-containing protein 33

Protein function

Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). /

Protein tissue specificity

Expressed in stem cells at the bottom of the crypts of the colon (at protein level). Expressed in colon adenomas and adenocarcinomas (at protein level). Expressed in brain, lung, liver, spleen, thymus, prostate, kidney, testis, heart, placenta, pancreas, small intestine, ovary, colon, skeletal muscle and hematopoietic progenitors.

Involvement in disease

Note: A chromosomal aberration involving TRIM33 is found in papillary thyroid carcinomas (PTCs). Translocation t(1;10)(p13;q11) with RET. The translocation generates the TRIM33/RET (PTC7) oncogene. .

Protein sequence and domain

Belongs to the TRIM/RBCC family. / Contains 2 B box-type zinc fingers. / Contains 1 bromo domain. / Contains 1 PHD-type zinc finger. / Contains 1 RING-type zinc finger.

Protein post-translational modifications

Sumoylated with SUMO1.

Protein cellular localization

Nucleus

Research area

All research areas>Transcription Regulators>TIF1
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize TIF1gamma Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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