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Mouse Monoclonal TIP60 antibody [3F9] (STJ98422)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
KAT5 antibody, HTATIP antibody, TIP60 antibody,|60 kDa Tat interactive protein antibody|60 kDa Tat-interactive protein antibody|cPLA(2) interacting protein antibody|cPLA(2)-interacting protein antibody|cPLA2 antibody|cPLA2 interacting protein antibody|ESA1 antibody|Histone acetyltransferase HTATIP antibody|Histone acetyltransferase KAT5 antibody|HIV 1 Tat interactive protein antibody|HIV 1 Tat interactive protein, 60kDa antibody|HIV-1 Tat interactive protein antibody|HTATIP antibody|HTATIP1 antibody|K(lysine) acetyltransferase 5 antibody|K-acetyltransferase 5 antibody|KAT5 antibody|KAT5_HUMAN antibody|Lysine acetyltransferase 5 antibody|PLIP antibody|Tat interacting protein, 60kDa antibody|TIP antibody|Tip60 antibody|Anti-KAT5 / Tip60 antibody (ab23886)
SCBT cat No: To be updated
TIP60 Monoclonal Antibody
|Catalogue No.|| |
TIP60 Monoclonal Antibody detects endogenous levels of TIP60 protein.
Purified recombinant fragment of human TIP60 expressed in E Coli
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
TIP60 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
TIP60 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Histone acetyltransferase KAT5 antibody, 60 kDa Tat-interactive protein antibody, Tip60 antibody, Histone acetyltransferase HTATIP antibody, HIV-1 Tat interactive protein antibody, Lysine acetyltransferase 5 antibody, cPLAantibody, 2 antibody,-interacting protein antibody
|Protein names|| |
Histone acetyltransferase KAT5 , 60 kDa Tat-interactive protein , Tip60 , Histone acetyltransferase HTATIP , HIV-1 Tat interactive protein , Lysine acetyltransferase 5 , cPLA, 2 ,-interacting protein
|Protein function|| |
Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity . / Acetyl-CoA + [histone] = CoA + acetyl-[histone].
|Protein sequence and domain|| |
Belongs to the MYST (SAS/MOZ) family. / Contains 1 C2HC-type zinc finger. / Contains 1 MYST-type HAT (histone acetyltransferase) domain.
|Protein post-translational modifications|| |
Sumoylated by UBE2I at Lys-430 and Lys-451, leading to increase of its histone acetyltransferase activity in UV-induced DNA damage response, as well as its translocation to nuclear bodies. / Phosphorylated on Ser-86 and Ser-90; enhanced during G2/M phase. The phosphorylated form has a higher HAT activity. / Ubiquitinated by MDM2, leading to its proteasome-dependent degradation. / Autoacetylation at Lys-327 is required for proper function.
|Protein cellular localization|| |
Nucleus / Nucleus > nucleolus / Cytoplasm > perinuclear region
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St John’s Laboratory Ltd.
|Product type|| |
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