Mouse Monoclonal TLR2 antibody [2D6] (STJ98423)

$379.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Mouse Monoclonal TLR2 antibody [2D6] (STJ98423)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for TLR2 Monoclonal Antibody.

Alternative names:

Check alternative names for the antibody

Expand

TLR2 antibody, TIL4 antibody,|CD282 antibody|CD282 antigen antibody|TIL 4 antibody|TIL4 antibody|TLR 2 antibody|TLR2 antibody|TLR2_HUMAN antibody|Toll like receptor 2 antibody|Toll like receptor 2 precursor antibody|Toll-like receptor 2 antibody|Toll/interleukin 1 receptor like 4 antibody|Toll/interleukin 1 receptor like protein 4 antibody|Toll/interleukin receptor like protein 4 antibody|Toll/interleukin-1 receptor-like protein 4 antibody|Anti-TLR2 antibody [TL2.1] (ab9100)
SCBT cat No: To be updated

 

Name

TLR2 Monoclonal Antibody

Catalogue No.

STJ98423

Reactivity

Human

Specificity

TLR2 Monoclonal Antibody detects endogenous levels of TLR2 protein.

Immunogen

Purified recombinant fragment of human TLR2 expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

TLR2 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

TLR2 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Toll-like receptor 2 antibody, Toll/interleukin-1 receptor-like protein 4 antibody, CD antigen CD282 antibody

Database links

Human UniProt/Swiss-Prot:O60603;Mouse UniPort/Swiss-Prot: Q9QUN7;Rat UniProt/Swiss-Port: Q6YGU2;Human Entrez Gene: 7097;Mouse Entrez Gene: 24088;Rat Entrez Gene: Rn.46387

Protein names

Toll-like receptor 2 , Toll/interleukin-1 receptor-like protein 4 , CD antigen CD282

Protein function

Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides . Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins . Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6 . Acts as a receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PhoS1 (pstS1), some lipoproteins are dependent on other coreceptors (TLR1, CD14 and/or CD36).The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen . Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides .

Protein tissue specificity

Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.

Protein sequence and domain

Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12. / The ATG16L1-binding motif mediates interaction with ATG16L1. / Belongs to the Toll-like receptor family. / Contains 19 LRR (leucine-rich) repeats. / Contains 1 LRRCT domain. / Contains 1 TIR domain.

Protein post-translational modifications

Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.

Protein cellular localization

Membrane / Single-pass type I membrane protein / Cytoplasmic vesicle > phagosome membrane / Single-pass type I membrane protein / Membrane raft

Research area

All research areas>Membrane Receptors>TLR
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize TLR2 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!