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Mouse Monoclonal TLR2 antibody [2D6] (STJ98423)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
TLR2 antibody, TIL4 antibody,|CD282 antibody|CD282 antigen antibody|TIL 4 antibody|TIL4 antibody|TLR 2 antibody|TLR2 antibody|TLR2_HUMAN antibody|Toll like receptor 2 antibody|Toll like receptor 2 precursor antibody|Toll-like receptor 2 antibody|Toll/interleukin 1 receptor like 4 antibody|Toll/interleukin 1 receptor like protein 4 antibody|Toll/interleukin receptor like protein 4 antibody|Toll/interleukin-1 receptor-like protein 4 antibody|Anti-TLR2 antibody [TL2.1] (ab9100)
SCBT cat No: To be updated
TLR2 Monoclonal Antibody
|Catalogue No.|| |
TLR2 Monoclonal Antibody detects endogenous levels of TLR2 protein.
Purified recombinant fragment of human TLR2 expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
TLR2 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
TLR2 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Toll-like receptor 2 antibody, Toll/interleukin-1 receptor-like protein 4 antibody, CD antigen CD282 antibody
|Protein names|| |
Toll-like receptor 2 , Toll/interleukin-1 receptor-like protein 4 , CD antigen CD282
|Protein function|| |
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides . Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins . Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6 . Acts as a receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PhoS1 (pstS1), some lipoproteins are dependent on other coreceptors (TLR1, CD14 and/or CD36).The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen . Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides .
|Protein tissue specificity|| |
Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.
|Protein sequence and domain|| |
Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12. / The ATG16L1-binding motif mediates interaction with ATG16L1. / Belongs to the Toll-like receptor family. / Contains 19 LRR (leucine-rich) repeats. / Contains 1 LRRCT domain. / Contains 1 TIR domain.
|Protein post-translational modifications|| |
Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
|Protein cellular localization|| |
Membrane / Single-pass type I membrane protein / Cytoplasmic vesicle > phagosome membrane / Single-pass type I membrane protein / Membrane raft
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St John’s Laboratory Ltd.
|Product type|| |
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