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Mouse Monoclonal TORC1 antibody (STJ98565)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, FC, IF
Recommended dilution: WB 1:1000-1:2000; FC 1:100-1:200; IF 1:100-1:500
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
CRTC1 antibody, KIAA0616 antibody, MECT1 antibody, TORC1 antibody, WAMTP1 antibody,|KIAA0616 antibody|CREB regulated transcription coactivator 1 antibody|CREB-regulated transcription coactivator 1 antibody|CRTC1 antibody|CRTC1_HUMAN antibody|FLJ14027 antibody|MECT 1 antibody|Mucoepidermoid carcinoma translocated 1 antibody|Mucoepidermoid carcinoma translocated protein 1 antibody|TORC-1 antibody|TORC1 antibody|Transducer of CREB protein 1 antibody|Transducer of regulated cAMP response element binding protein 1 antibody|Transducer of regulated cAMP response element-binding protein (CREB) 1 antibody|Transducer of regulated cAMP response element-binding protein 1 antibody|WAMTP1 antibody|Anti-TORC1 antibody [EPR3382] (ab92477)
SCBT cat No: To be updated
TORC1 Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat, Pig
TORC1 Monoclonal Antibody detects endogenous levels of TORC1 protein.
Purified recombinant human TORC1 (N-terminus) protein fragments expressed in Ecoli
WB, FC, IF
|Recommended dilution|| |
WB 1:1000-1:2000; FC 1:100-1:200; IF 1:100-1:500
TORC1 Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
TORC1 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
CREB-regulated transcription coactivator 1 antibody, Mucoepidermoid carcinoma translocated protein 1 antibody, Transducer of regulated cAMP response element-binding protein 1 antibody, TORC-1 antibody, Transducer of CREB protein 1 antibody
|Protein names|| |
CREB-regulated transcription coactivator 1 , Mucoepidermoid carcinoma translocated protein 1 , Transducer of regulated cAMP response element-binding protein 1 , TORC-1 , Transducer of CREB protein 1
|Protein function|| |
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 ‘Ser-133’ phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.
|Protein tissue specificity|| |
Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney.
|Involvement in disease|| |
Note: A chromosomal aberration involving CRTC1 is found in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. Translocation t(11;19)(q21;p13) with MAML2. The fusion protein consists of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas.
|Protein sequence and domain|| |
Belongs to the TORC family.
|Protein post-translational modifications|| |
Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1 (By similarity).
|Protein cellular localization|| |
Cytoplasm / Nucleus
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St John’s Laboratory Ltd.
|Product type|| |
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