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Mouse Monoclonal TORC2 antibody [5B10] (STJ98427)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, FC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for TORC2 Monoclonal Antibody.
Check alternative names for the antibodyExpand
CRTC2 antibody, TORC2 antibody,|CREB regulated transcription coactivator 2 antibody|CREB-regulated transcription coactivator 2 antibody|CRTC2 antibody|CRTC2_HUMAN antibody|RP11-422P24.6 antibody|TORC-2 antibody|torc2 antibody|Transducer of CREB protein 2 antibody|Transducer of regulated cAMP response element-binding protein antibody|Transducer of regulated cAMP response element-binding protein (CREB) 2 antibody|Transducer of regulated cAMP response element-binding protein 2 antibody|Transducer of regulated CREB protein 2 antibody|Anti-TORC2 antibody [EPR3384(2)] (ab109081)
SCBT cat No: To be updated
TORC2 Monoclonal Antibody
|Catalogue No.|| |
TORC2 Monoclonal Antibody detects endogenous levels of TORC2 protein.
Purified recombinant fragment of human TORC2 expressed in E Coli
WB, IHC, IF, FC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
TORC2 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
TORC2 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
CREB-regulated transcription coactivator 2 antibody, Transducer of regulated cAMP response element-binding protein 2 antibody, TORC-2 antibody, Transducer of CREB protein 2 antibody
|Protein names|| |
CREB-regulated transcription coactivator 2 , Transducer of regulated cAMP response element-binding protein 2 , TORC-2 , Transducer of CREB protein 2
|Protein function|| |
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 ‘Ser-133’ phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
|Protein tissue specificity|| |
Most abundantly expressed in the thymus. Present in both B and T-lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle. Lower levels found in brain, colon, heart, kidney, prostate, small intestine and stomach. Weak expression in liver and pancreas.
|Protein sequence and domain|| |
Belongs to the TORC family.
|Protein post-translational modifications|| |
Phosphorylation/dephosphorylation states of Ser-171 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation, is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs (SIK1 and SIK2) by LKB1. Both insulin and AMPK increase this phosphorylation of CRTC2 while glucagon suppresses it. Phosphorylation at Ser-274 by MARK2 is induced under low glucose conditions and dephosphorylated in response to glucose influx. Phosphorylation at Ser-274 promotes interaction with 14-3-3 proteins and translocation to the cytoplasm. / Asymmetric dimethylation of arginine resisues by PRMT6 enhances the association of CRTC2 with CREB on the promoters of gluconeogenic genes.
|Protein cellular localization|| |
Cytoplasm / Nucleus
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St John’s Laboratory Ltd.
|Product type|| |
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