Mouse Monoclonal Trk C antibody [7H6] (STJ98431)

$379.00

Reactivity: Human
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Trk C antibody [7H6] (STJ98431)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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NTRK3 antibody, TRKC antibody,|BDNF/NT-3 growth factors receptor antibody|Tyrosine kinase receptor A antibody|Tyrosine kinase receptor antibody|Anti-TrkA+B+C antibody [EPR17341] (ab181560)
SCBT cat No: sc-135645|sc-66159|sc-135790|sc-135789|sc-71947|sc-5839|sc-398471|

 

Name

Trk C Monoclonal Antibody

Catalogue No.

STJ98431

Reactivity

Human

Specificity

Trk C Monoclonal Antibody detects endogenous levels of Trk C protein.

Immunogen

Purified recombinant extracellular fragment of human Trk C (aa32-429) fused with hIgGFc tag expressed in HEK293 cells

Host

Mouse

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

Trk C Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

Trk C Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

NT-3 growth factor receptor antibody, GP145-TrkC antibody, Trk-C antibody, Neurotrophic tyrosine kinase receptor type 3 antibody, TrkC tyrosine kinase antibody

Database links

Human UniProt/Swiss-Prot:Q16288;Mouse UniPort/Swiss-Prot: Q6VNS1;Rat UniProt/Swiss-Port: Q03351;Human Entrez Gene: 4916;Mouse Entrez Gene: 18213;Rat Entrez Gene: Rn.9963

Protein names

NT-3 growth factor receptor , GP145-TrkC , Trk-C , Neurotrophic tyrosine kinase receptor type 3 , TrkC tyrosine kinase

Protein function

Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Protein tissue specificity

Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.

Involvement in disease

Note: Defects in NTRK3 are associated with susceptibility to congenital heart defects (CHD). A disease characterized by congenital developmental abnormalities involving structures of the heart. CHD are the most common major birth defects and the leading cause of death from congenital malformations. .

Protein sequence and domain

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. / Contains 2 Ig-like C2-type (immunoglobulin-like) domains. / Contains 2 LRR (leucine-rich) repeats. / Contains 1 LRRCT domain. / Contains 1 protein kinase domain.

Protein post-translational modifications

Ligand-mediated auto-phosphorylation.

Protein cellular localization

Membrane; Single-pass type I membrane protein

Research area

All research areas>Neurobiology>Trk
(View all antibody categories related to Neurobiology)

Note

AntibodyPlus can customize Trk C Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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