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Mouse Monoclonal Tubulin beta antibody (STJ98566)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB
Recommended dilution: WB 1:1000-1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for Tubulin beta Monoclonal Antibody.
Check alternative names for the antibodyExpand
TUBB1 antibody,|2810484G07Rik antibody|Beta tubulin 1, class VI antibody|Class VI beta tubulin antibody|dJ543J19.4 antibody|M(beta)1 antibody|TBB1_HUMAN antibody|TUBB1 antibody|Tubulin beta 1 class VI antibody|Tubulin beta-1 chain antibody|Tubulin, beta 1 antibody|tubulin, beta1 antibody|Anti-beta I Tubulin antibody [EPR16778] (ab179511)
SCBT cat No: To be updated
Tubulin beta Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat, Cow, Rabbit
Tubulin beta Monoclonal Antibody detects endogenous levels of Tubulin beta protein.
Purified recombinant human Tubulin beta protein fragments expressed in Ecoli
|Recommended dilution|| |
Tubulin beta Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
Tubulin beta Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Tubulin beta-1 chain antibody
|Protein names|| |
Tubulin beta-1 chain
|Protein function|| |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
|Protein tissue specificity|| |
Hematopoietic cell-specific. Major isotype in leukocytes, where it represents 50% of all beta-tubulins.
|Involvement in disease|| |
Macrothrombocytopenia, autosomal dominant, TUBB1-related (MAD-TUBB1) [MIM:613112]: A congenital blood disorder characterized by increased platelet size and decreased number of circulating platelets. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the tubulin family.
|Protein post-translational modifications|| |
Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group . Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold . / Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable).
|Protein cellular localization|| |
Cytoplasm > cytoskeleton
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St John’s Laboratory Ltd.
|Product type|| |
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