Mouse Monoclonal Tubulin beta antibody (STJ98566)

$379.00

Reactivity: Human, Mouse, Rat, Cow, Rabbit
Applications: WB
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Tubulin beta antibody (STJ98566)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB

Recommended dilution: WB 1:1000-1:2000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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TUBB1 antibody,|2810484G07Rik antibody|Beta tubulin 1, class VI antibody|Class VI beta tubulin antibody|dJ543J19.4 antibody|M(beta)1 antibody|TBB1_HUMAN antibody|TUBB1 antibody|Tubulin beta 1 class VI antibody|Tubulin beta-1 chain antibody|Tubulin, beta 1 antibody|tubulin, beta1 antibody|Anti-beta I Tubulin antibody [EPR16778] (ab179511)
SCBT cat No: To be updated

 

Name

Tubulin beta Monoclonal Antibody

Catalogue No.

STJ98566

Reactivity

Human, Mouse, Rat, Cow, Rabbit

Specificity

Tubulin beta Monoclonal Antibody detects endogenous levels of Tubulin beta protein.

Immunogen

Purified recombinant human Tubulin beta protein fragments expressed in Ecoli

Host

Mouse

Applications

WB

Recommended dilution

WB 1:1000-1:2000

Clonality

Monoclonal

Conjugation

Unconjugated

Formulation

Tubulin beta Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Concentration

1 mg/ml

Purification

Tubulin beta Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Tubulin beta-1 chain antibody

Database links

Human UniProt/Swiss-Prot:Q9H4B7;Mouse UniPort/Swiss-Prot: A2AQ07;Rat UniProt/Swiss-Port: M0R8B6;Human Entrez Gene: 81027;Mouse Entrez Gene: 545486;

Protein names

Tubulin beta-1 chain

Protein function

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).

Protein tissue specificity

Hematopoietic cell-specific. Major isotype in leukocytes, where it represents 50% of all beta-tubulins.

Involvement in disease

Macrothrombocytopenia, autosomal dominant, TUBB1-related (MAD-TUBB1) [MIM:613112]: A congenital blood disorder characterized by increased platelet size and decreased number of circulating platelets. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the tubulin family.

Protein post-translational modifications

Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group . Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold . / Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable).

Protein cellular localization

Cytoplasm > cytoskeleton

Research area

All research areas>Structural Proteins>Tubulin
(View all antibody categories related to Structural Proteins)

Note

AntibodyPlus can customize Tubulin beta Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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