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Mouse Monoclonal Tyro3 antibody [1C10E8; 9A3F2] (STJ98441)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
TYRO3 antibody, BYK antibody, DTK antibody, RSE antibody, SKY antibody, TIF antibody,|AI323366 antibody|Brt antibody|Bruton agammaglobulinemia tyrosine kinase antibody|BYK antibody|c-mer antibody|c-mer proto-oncogene tyrosine kinase antibody|Dtk antibody|Etk 2 antibody|Eyk antibody|FLJ16467 antibody|Mer antibody|MER receptor tyrosine kinase antibody|MERTK antibody|MGC133349 antibody|Nyk antibody|OTTMUSP00000017810 antibody|rdy antibody|Receptor tyrosine kinase antibody|Receptor tyrosine kinase MerTK antibody|Receptor tyrosine tinase gene probably the gene for Rdy antibody|Retinal dystrophy antibody|RP23-30M20.1 antibody|RP23-356L21.1 antibody|RP38 antibody|RSE antibody|Sky antibody|STK kinase antibody|Tif antibody|TYRO3 antibody|TYRO3 protein tyrosine kinase 3 antibody|TYRO3 protein tyrosine kinase antibody|Tyrosine protein kinase byk antibody|Tyrosine protein kinase DTK antibody|Tyrosine protein kinase RSE antibody|Tyrosine protein kinase SKY antibody|Anti-MER + SKY antibody (ab79223)
SCBT cat No: sc-515338|sc-66395|sc-66397|
Tyro3 Monoclonal Antibody
|Catalogue No.|| |
Tyro3 Monoclonal Antibody detects endogenous levels of Tyro3 protein.
Purified recombinant fragment of Tyro3 expressed in E Coli
WB, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000
Tyro3 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
Tyro3 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Tyrosine-protein kinase receptor TYRO3 antibody, Tyrosine-protein kinase BYK antibody, Tyrosine-protein kinase DTK antibody, Tyrosine-protein kinase RSE antibody, Tyrosine-protein kinase SKY antibody, Tyrosine-protein kinase TIF antibody
|Protein names|| |
Tyrosine-protein kinase receptor TYRO3 , Tyrosine-protein kinase BYK , Tyrosine-protein kinase DTK , Tyrosine-protein kinase RSE , Tyrosine-protein kinase SKY , Tyrosine-protein kinase TIF
|Protein function|| |
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. / (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope . Acts as a receptor for ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope . / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
|Protein tissue specificity|| |
Abundant in the brain and lower levels in other tissues.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. / Contains 2 fibronectin type-III domains. / Contains 2 Ig-like C2-type (immunoglobulin-like) domains. / Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
|Protein cellular localization|| |
Cell membrane; Single-pass type I membrane protein
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St John’s Laboratory Ltd.
|Product type|| |
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