Mouse Monoclonal Tyro3 antibody [6D6F10] (STJ98442)

$379.00

Reactivity: Human
Applications: IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Tyro3 antibody [6D6F10] (STJ98442)

Supplier: St John’s Laboratory Ltd.

Recommended applications: IF, ELISA

Recommended dilution: IF 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

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Alternative names:

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TYRO3 antibody, BYK antibody, DTK antibody, RSE antibody, SKY antibody, TIF antibody,|AI323366 antibody|Brt antibody|Bruton agammaglobulinemia tyrosine kinase antibody|BYK antibody|c-mer antibody|c-mer proto-oncogene tyrosine kinase antibody|Dtk antibody|Etk 2 antibody|Eyk antibody|FLJ16467 antibody|Mer antibody|MER receptor tyrosine kinase antibody|MERTK antibody|MGC133349 antibody|Nyk antibody|OTTMUSP00000017810 antibody|rdy antibody|Receptor tyrosine kinase antibody|Receptor tyrosine kinase MerTK antibody|Receptor tyrosine tinase gene probably the gene for Rdy antibody|Retinal dystrophy antibody|RP23-30M20.1 antibody|RP23-356L21.1 antibody|RP38 antibody|RSE antibody|Sky antibody|STK kinase antibody|Tif antibody|TYRO3 antibody|TYRO3 protein tyrosine kinase 3 antibody|TYRO3 protein tyrosine kinase antibody|Tyrosine protein kinase byk antibody|Tyrosine protein kinase DTK antibody|Tyrosine protein kinase RSE antibody|Tyrosine protein kinase SKY antibody|Anti-MER + SKY antibody (ab79223)
SCBT cat No: sc-515338|sc-66395|sc-66397|

 

Name

Tyro3 Monoclonal Antibody

Catalogue No.

STJ98442

Reactivity

Human

Specificity

Tyro3 Monoclonal Antibody detects endogenous levels of Tyro3 protein.

Immunogen

Purified recombinant fragment of Tyro3 (aa138-321) expressed in E Coli

Host

Mouse

Applications

IF, ELISA

Recommended dilution

IF 1:200-1:1000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

Tyro3 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

Tyro3 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Tyrosine-protein kinase receptor TYRO3 antibody, Tyrosine-protein kinase BYK antibody, Tyrosine-protein kinase DTK antibody, Tyrosine-protein kinase RSE antibody, Tyrosine-protein kinase SKY antibody, Tyrosine-protein kinase TIF antibody

Database links

Human UniProt/Swiss-Prot:Q06418;Mouse UniPort/Swiss-Prot: P55144;Rat UniProt/Swiss-Port: P55146;Human Entrez Gene: 7301;Mouse Entrez Gene: 22174;Rat Entrez Gene: Rn.8883

Protein names

Tyrosine-protein kinase receptor TYRO3 , Tyrosine-protein kinase BYK , Tyrosine-protein kinase DTK , Tyrosine-protein kinase RSE , Tyrosine-protein kinase SKY , Tyrosine-protein kinase TIF

Protein function

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. / (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope . Acts as a receptor for ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope . / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Protein tissue specificity

Abundant in the brain and lower levels in other tissues.

Protein sequence and domain

Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. / Contains 2 fibronectin type-III domains. / Contains 2 Ig-like C2-type (immunoglobulin-like) domains. / Contains 1 protein kinase domain.

Protein post-translational modifications

Autophosphorylated.

Protein cellular localization

Cell membrane; Single-pass type I membrane protein

Research area

All research areas>Kinases and Phosphatases>Tyro3
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize Tyro3 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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