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Mouse Monoclonal WDR79 antibody (STJ98569)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB
Recommended dilution: WB 1:1000-1:2000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
WRAP53 antibody, TCAB1 antibody, WDR79 antibody,|FLJ10385 antibody|TCAB1 antibody|Telomerase Cajal body protein 1 antibody|WAP53_HUMAN antibody|WD repeat containing protein 79 antibody|WD repeat-containing protein 79 antibody|WD40 repeat-containing protein encoding RNA antisense to p53 antibody|Wrap53 antibody|Anti-WDR79 antibody (ab99376)
SCBT cat No: To be updated
WDR79 Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
WDR79 Monoclonal Antibody detects endogenous levels of WDR79 protein.
Purified recombinant human WDR79 protein fragments expressed in Ecoli
|Recommended dilution|| |
WDR79 Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
WDR79 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Telomerase Cajal body protein 1 antibody, WD repeat-containing protein 79 antibody, WD repeat-containing protein WRAP53 antibody, WD40 repeat-containing protein antisense to TP53 gene antibody
|Protein names|| |
Telomerase Cajal body protein 1 , WD repeat-containing protein 79 , WD repeat-containing protein WRAP53 , WD40 repeat-containing protein antisense to TP53 gene
|Protein function|| |
Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post-transcriptional level; it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage.
|Protein tissue specificity|| |
Expressed in all tissues and cell lines examined.
|Involvement in disease|| |
Dyskeratosis congenita, autosomal recessive, 3 (DKCB3) [MIM:613988]: A rare multisystem disorder caused by defective telomere maintenance. It is characterized by progressive bone marrow failure, and the clinical triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Common but variable features include premature graying, aplastic anemia, low platelets, osteoporosis, pulmonary fibrosis, and liver fibrosis among others. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Contains 6 WD repeats.
|Protein cellular localization|| |
Nucleus > Cajal body / Cytoplasm
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St John’s Laboratory Ltd.
|Product type|| |
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