Mouse Monoclonal Wnt-1 antibody [10C8] (STJ98451)

$379.00

Reactivity: Human, Mouse
Applications: WB, IHC, IF, FC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Wnt-1 antibody [10C8] (STJ98451)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF, FC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Wnt-1 Monoclonal Antibody.

Alternative names:

Check alternative names for the antibody

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WNT1 antibody, INT1 antibody,|BMND16 antibody|INT1 antibody|OI15 antibody|oncogene Int1 antibody|Proto oncogene protein Wnt 1 antibody|Proto-oncogene Int-1 homolog antibody|Proto-oncogene Wnt-1 antibody|Wingless type MMTV integration site family member 1 antibody|wingless-type MMTV integration site family, member 1 (oncogene INT1) antibody|Wnt 1 antibody|wnt1 antibody|WNT1_HUMAN antibody|Anti-Wnt1 antibody (ab15251)
SCBT cat No: To be updated

 

Name

Wnt-1 Monoclonal Antibody

Catalogue No.

STJ98451

Reactivity

Human, Mouse

Specificity

Wnt-1 Monoclonal Antibody detects endogenous levels of Wnt-1 protein.

Immunogen

Purified recombinant fragment of Wnt-1 expressed in E Coli

Host

Mouse

Applications

WB, IHC, IF, FC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

Wnt-1 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

Wnt-1 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Proto-oncogene Wnt-1 antibody, Proto-oncogene Int-1 homolog antibody

Database links

Human UniProt/Swiss-Prot:P04628;Mouse UniPort/Swiss-Prot: P04426;Rat UniProt/Swiss-Port: D4A9J2;Human Entrez Gene: 7471;Mouse Entrez Gene: 22408;Rat Entrez Gene: Rn.138108

Protein names

Proto-oncogene Wnt-1 , Proto-oncogene Int-1 homolog

Protein function

Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. Has a role in osteoblast function and bone development.

Involvement in disease

Osteoporosis (OSTEOP) [MIM:166710]: A systemic skeletal disorder characterized by decreased bone mass and deterioration of bone microarchitecture without alteration in the composition of bone. The result is fragile bones and an increased risk of fractures, even after minimal trauma. Osteoporosis is a chronic condition of multifactorial etiology and is usually clinically silent until a fracture occurs. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.; Osteogenesis imperfecta 15 (OI15) [MIM:615220]: An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI15 is characterized by early-onset recurrent fractures, bone deformity, significant reduction of bone density, short stature, and, in some patients, blue sclerae. Tooth development and hearing are normal. Learning and developmental delays and brain anomalies have been observed in some patients. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the Wnt family.

Protein post-translational modifications

Palmitoleylation is required for efficient binding to frizzled receptors. Palmitoleylation is necessary for proper trafficking to cell surface (Probable). Depalmitoleylated by NOTUM, leading to inhibit Wnt signaling pathway (By similarity).

Protein cellular localization

Secreted > extracellular space > extracellular matrix

Research area

All research areas>Signaling Intermediates>Wnt
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize Wnt-1 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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