Mouse Monoclonal Wnt-5a antibody [3D10] (STJ98454)

$379.00

Reactivity: Human
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Wnt-5a antibody [3D10] (STJ98454)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Wnt-5a Monoclonal Antibody.

Alternative names:

Check alternative names for the antibody

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SCBT cat No: To be updated

 

Name

Wnt-5a Monoclonal Antibody

Catalogue No.

STJ98454

Reactivity

Human

Specificity

Wnt-5a Monoclonal Antibody detects endogenous levels of Wnt-5a protein.

Immunogen

Purified recombinant fragment of Wnt-5a expressed in E Coli

Host

Mouse

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

Wnt-5a Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

Wnt-5a Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Protein Wnt-5a antibody

Database links

Human UniProt/Swiss-Prot:P41221;Mouse UniPort/Swiss-Prot: P22725;Rat UniProt/Swiss-Port: F2Z3U1;Human Entrez Gene: 7474;Mouse Entrez Gene: 22418;Rat Entrez Gene: Rn.48749

Protein names

Protein Wnt-5a

Protein function

Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.

Protein tissue specificity

Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level).

Involvement in disease

Robinow syndrome, autosomal dominant 1 (DRS1) [MIM:180700]: A disease characterized by short-limb dwarfism, costovertebral segmentation defects and abnormalities of the head, face and external genitalia. The clinical signs are generally milder in dominant cases. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the Wnt family.

Protein post-translational modifications

Glycosylation is necessary for secretion but not for activity. / Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition. / Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT5A.

Protein cellular localization

Secreted > extracellular space > extracellular matrix

Research area

All research areas>Signaling Intermediates>Wnt
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize Wnt-5a Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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