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Mouse Monoclonal Wnt-5a antibody [6F2] (STJ98453)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for Wnt-5a Monoclonal Antibody.
Check alternative names for the antibodyExpand
WNT5A antibody,|hWNT 5A antibody|hWNT5A antibody|Protein Wnt 5a antibody|Protein Wnt-5a antibody|Protein Wnt5a antibody|Wingless type MMTV integration site family member 5A antibody|Wnt 5a antibody|WNT 5A protein antibody|WNT 5A protein precursor antibody|WNT5A antibody|WNT5A protein precursor antibody|WNT5A_HUMAN antibody|Anti-Wnt5a antibody (ab72583)
SCBT cat No: To be updated
Wnt-5a Monoclonal Antibody
|Catalogue No.|| |
Wnt-5a Monoclonal Antibody detects endogenous levels of Wnt-5a protein.
Purified recombinant fragment of Wnt-5a expressed in E Coli
WB, IHC, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000
Wnt-5a Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
Wnt-5a Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Protein Wnt-5a antibody
|Protein names|| |
|Protein function|| |
Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.
|Protein tissue specificity|| |
Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level).
|Involvement in disease|| |
Robinow syndrome, autosomal dominant 1 (DRS1) [MIM:180700]: A disease characterized by short-limb dwarfism, costovertebral segmentation defects and abnormalities of the head, face and external genitalia. The clinical signs are generally milder in dominant cases. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the Wnt family.
|Protein post-translational modifications|| |
Glycosylation is necessary for secretion but not for activity. / Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition. / Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT5A.
|Protein cellular localization|| |
Secreted > extracellular space > extracellular matrix
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St John’s Laboratory Ltd.
|Product type|| |
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