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Rabbit Polyclonal Acetyl-CBP (K1535) antibody (STJ90134)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for CBP (Acetyl Lys1535) Polyclonal Antibody.
Check alternative names for the antibodyExpand
CREBBP antibody, CBP antibody,|CBP antibody|Csk binding protein antibody|Csk-binding protein antibody|FLJ37858 antibody|MGC138364 antibody|PAG 1 antibody|PAG antibody|PAG1 antibody|PAG1_HUMAN antibody|Phosphoprotein associated with glycosphingolipid enriched microdomains 1 antibody|Phosphoprotein associated with glycosphingolipid enriched microdomains antibody|Phosphoprotein associated with glycosphingolipid microdomains 1 antibody|Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 antibody|Protein Associated with Glycosphingolipid Enriched Microdomains antibody|Transmembrane adapter protein PAG antibody|Transmembrane phosphoprotein Cbp antibody|Anti-KAT3A / CBP antibody – ChIP Grade (ab2832)
SCBT cat No: sc-1211|sc-293026|sc-369|sc-7300|sc-583|sc-365915|
CBP (Acetyl Lys1535) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Acetyl-CBP (K1535) Polyclonal Antibody detects endogenous levels of CBP protein only when acetylated at K1535.
Synthesized acetyl-peptide derived from CBP (Acetyl Lys1535) at AA range 1480-1550
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;
|Molecular weight|| |
CBP (Acetyl Lys1535) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
CBP (Acetyl Lys1535) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
CREB-binding protein antibody,
|Protein names|| |
CREB-binding protein ,
|Protein function|| |
Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) . / Acetyl-CoA + [histone] = CoA + acetyl-[histone].
|Involvement in disease|| |
Note: Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with KMT2A/MLL1; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription.; Rubinstein-Taybi syndrome 1 (RSTS1) [MIM:180849]: A disorder characterized by craniofacial abnormalities, postnatal growth deficiency, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
The KIX domain mediates binding to HIV-1 Tat. / Contains 1 bromo domain. / Contains 1 CBP/p300-type HAT (histone acetyltransferase) domain. / Contains 1 KIX domain. / Contains 2 TAZ-type zinc fingers. / Contains 1 ZZ-type zinc finger.
|Protein post-translational modifications|| |
Methylation of the KIX domain by CARM1 blocks association with CREB. This results in the blockade of CREB signaling, and in activation of apoptotic response (By similarity). / Phosphorylated by CHUK/IKKA at Ser-1382 and Ser-1386; these phosphorylations promote cell growth by switching the binding preference of CREBBP from TP53 to NF-kappa-B. / Sumoylation negatively regulates transcriptional activity via the recruitment of DAAX. / Autoacetylation is required for binding to protein substrates, such as acetylated histones and acetylated TP53/p53.
|Protein cellular localization|| |
Cytoplasm / Nucleus
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St John’s Laboratory Ltd.
|Product type|| |
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