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Rabbit Polyclonal Acetyl-Cytokeratin 8 (K483) antibody (STJ90146)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC-P 1:100-300; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for Cytokeratin 8 (Acetyl Lys483) Polyclonal Antibody.
Check alternative names for the antibodyExpand
KRT8 antibody, CYK8 antibody,|CARD2 antibody|Cell proliferation inducing gene 46 protein antibody|Cell proliferation inducing protein 46 antibody|CK 8 antibody|CK-8 antibody|CK18 antibody|CK8 antibody|CYK18 antibody|CYK8 antibody|Cytokeratin 18 antibody|Cytokeratin 8 antibody|Cytokeratin-8 antibody|K18 antibody|K2C8 antibody|K2C8_HUMAN antibody|K8 antibody|Keratin 18 antibody|Keratin 8 antibody|Keratin antibody|Keratin type I cytoskeletal 18 antibody|keratin type II cytoskeletal 8 antibody|Keratin-8 antibody|KO antibody|KRT18 antibody|KRT8 antibody|type II cytoskeletal 8 antibody|Type-II keratin Kb8 antibody|Anti-Cytokeratin 8+18 antibody [EP1628Y] (ab53280)
SCBT cat No: sc-130312|sc-58736|sc-73480|sc-58737|sc-374275|sc-8020|sc-374274|sc-374027|sc-134484|sc-101459|sc-53266|sc-52324|
Cytokeratin 8 (Acetyl Lys483) Polyclonal Antibody
|Catalogue No.|| |
Acetyl-Cytokeratin 8 (K483) Polyclonal Antibody detects endogenous levels of Cytokeratin 8 protein only when acetylated at K483.
Synthesized acetyl-peptide derived from the human Cytokeratin 8 around the acetylation site of K483
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC-P 1:100-300; ELISA 1:20000;
|Molecular weight|| |
Cytokeratin 8 (Acetyl Lys483) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Cytokeratin 8 (Acetyl Lys483) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Keratin, type II cytoskeletal 8 antibody, Cytokeratin-8 antibody, CK-8 antibody, Keratin-8 antibody, K8 antibody, Type-II keratin Kb8 antibody
|Protein names|| |
Keratin, type II cytoskeletal 8 , Cytokeratin-8 , CK-8 , Keratin-8 , K8 , Type-II keratin Kb8
|Protein function|| |
Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
|Protein tissue specificity|| |
Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
|Involvement in disease|| |
Cirrhosis (CIRRH) [MIM:215600]: A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the intermediate filament family.
|Protein post-translational modifications|| |
Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization. / O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation. / O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
|Protein cellular localization|| |
Cytoplasm / Nucleus > nucleoplasm / Nucleus matrix
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St John’s Laboratory Ltd.
|Product type|| |
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